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Dentin phosphophoryn promotes cellular migration of human dental pulp cells
http://hdl.handle.net/10069/16409
http://hdl.handle.net/10069/164091aed3225-5dde-441f-a28e-9723966b6a38
名前 / ファイル | ライセンス | アクション |
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JouEnd34_575.pdf (200.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-04-11 | |||||
タイトル | ||||||
タイトル | Dentin phosphophoryn promotes cellular migration of human dental pulp cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phosphophoryn | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dentin sialophosphoprotein | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | migration | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | RGD motif | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | dental pulp cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reparative dentin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yasuda, Yoshiyuki
× Yasuda, Yoshiyuki× Izumikawa, Masanobu× Okamoto, Kuniaki× Tsukuba, Takayuki× Saito, Takashi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Dentin phosphophoryn (DPP) is a dentin sialophosphoprotein gene product that has an RGD motif and repeat sequences of aspartic acid and phosphoserine. To date, the function of DPP in the early stage of reparative dentin formation still remains unclear. The objective of this study was to evaluate the effects of DPP on pulp cell migration and proliferation. DPP promoted cell migration in a concentration-dependent manner, thus increasing it by about 3-fold at 1000 ng/mL compared with the control, but it had no effect on cell proliferation. Dephosphorylated DPP also promoted cell migration, similarly to DPP. However, cell migration was significantly suppressed by the addition of αvβ3 integrin antibody to the medium. Furthermore, porcine DPP-derived RGD peptide, but not its mutant RAD peptide, significantly promoted cell migration. These results indicated that the RGD motif of DPP plays an important role in the migration of human dental pulp cells. | |||||
書誌情報 |
Journal of Endodontics 巻 34, 号 5, p. 575-578, 発行日 2008-05 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00992399 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10614412 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.joen.2008.02.018 | |||||
権利 | ||||||
権利情報 | Copyright c 2008 American Association of Endodontists Published by Elsevier Inc. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Endodontics, 34(5), pp.575-578; 2008 |