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ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips
http://hdl.handle.net/10069/37249
http://hdl.handle.net/10069/37249aa54c77d-9a07-476e-a39f-cda80cb9788d
名前 / ファイル | ライセンス | アクション |
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JCB214_475.pdf (3.4 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-12 | |||||
タイトル | ||||||
タイトル | ERK signaling promotes cell motility by inducing the localization of myosin 1E to lamellipodial tips | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tanimura, Susumu
× Tanimura, Susumu× Hashizume, Junya× Arichika, Naoya× Watanabe, Kazushi× Ohyama, Kaname× Takeda, Kohsuke× Kohno, Michiaki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Signaling by extracellular signal-regulated kinase (ERK) plays an essential role in the induction of cell motility, but the precise mechanism underlying such regulation has remained elusive. We recently identified SH3P2 as a negative regulator of cell motility whose function is inhibited by p90 ribosomal S6 kinase (RSK)-mediated phosphorylation downstream of ERK. We here show that myosin 1E (Myo1E) is a binding partner of SH3P2 and that the interaction of the two proteins in the cytosol prevents the localization of Myo1E to the plasma membrane. Serum-induced phosphorylation of SH3P2 at Ser202 by RSK results in dissociation of Myo1E from SH3P2 in the cytosol and the subsequent localization of Myo1E to the tips of lamellipodia mediated by binding of its TH2 domain to F-actin. This translocation of Myo1E is essential for lamellipodium extension and consequent cell migration. The ERK signaling pathway thus promotes cell motility through regulation of the subcellular localization of Myo1E. | |||||
書誌情報 |
The Journal of Cell Biology 巻 214, 号 4, p. 475-489, 発行日 2016-08-08 |
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出版者 | ||||||
出版者 | Rockefeller University Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00219525 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 15408140 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1083/jcb.201503123 | |||||
権利 | ||||||
権利情報 | c 2016 Tanimura et al.This article is an open access article under a Creative Commons License (Attribution?Noncommercial?Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Journal of Cell Biology, 214(4), pp.475-489; 2016 |