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Protective Immunity Against Challenge Infection with Trichinella spiralis in the Rat
http://hdl.handle.net/10069/16824
http://hdl.handle.net/10069/168249713554b-097d-40f4-93bf-a6fa2751ead9
名前 / ファイル | ライセンス | アクション |
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acta_52_4_101.pdf (4.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-04-30 | |||||
タイトル | ||||||
タイトル | Protective Immunity Against Challenge Infection with Trichinella spiralis in the Rat | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Trichinella spiralis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Infection | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Excretory-secretory antigen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antibody isotype response | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T helper type cytokine | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Quan, Fu Shi
× Quan, Fu Shi× Bae, Jun Sang× Lee, Jeong Beom× Min, Young Ki× Yang, Hun Mo× Joo, Kyung-Whan× Cho, Sung-Weon× Lee, Joon-Sang× Nakayama, Toshiyuki× Sekine, Ichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Protective immunity and immune response were studied in rats after primarily infection with Trichinella spiralis. The parameters measured include serum antibody isotype responses, mesenteric lymph node (MLN) cell and spleen cell proliferation responses in vitro, and the levels of interferon (IFN)-γ, interleukin (IL)-2, IL-4 and IL-10 as markers of the T-helper (Th) subset. Protective immunity was assessed by the degree of expulsion of adult worms from the rat intestine. Protective immunity against adult worms after challenge infection was 99.80%. Although IFN-γ, IL-2, IL-4 and IL-10 in both the MLNs and spleen were detected, IFN-γ and IL-2 levels were higher in the spleen than in the MLNs, and IL-4 and an increased amount of IL-10 was released in the MLNs as compared to the spleen. The levels of the specific immunoglobulins (Ig) G, IgM, IgG1 and IgG2a on week 6 after primary infection, and on day 7 after challenge infection, were higher as compared to levels in uninfected rats that only received a challenge infection (P ? 0.001), whereas the antibody level of IgG1 was significantly elevated from that of IgG2a (P ? 0.001). These results demonstrate that Th1 type responses predominated. In addition, as Th2 type cytokines were also produced, it is proposed that the protective immunity by primary infection was also related to the Th1 type responses. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 52, 号 4, p. 101-106, 発行日 2008-03 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/52.101 | |||||
sortkey | ||||||
P00101-P00106 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2007, 52(4), p.101-106 |