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Simultaneous determination of mycophenolic acid and its acyl and phenol glucuronide metabolites in human serum by capillary zone electrophoresis
http://hdl.handle.net/10069/16873
http://hdl.handle.net/10069/16873c1f90209-11b0-4c82-8b8b-8cc4e2ca3234
名前 / ファイル | ライセンス | アクション |
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JPBA47_201.pdf (189.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-05-07 | |||||
タイトル | ||||||
タイトル | Simultaneous determination of mycophenolic acid and its acyl and phenol glucuronide metabolites in human serum by capillary zone electrophoresis | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Capillary zone electrophoresis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mycophenolic acid | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Acyl glucuronide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phenol glucuronide | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Renal transplant patient | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ohyama, Kaname
× Ohyama, Kaname× Kishikawa, Naoya× Nakagawa, Hiroo× Kuroda, Naotaka× Nishikido, Masaharu× Teshima, Mugen× To, Hideto× Kitahara, Takashi× Sasaki, Hitoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A simple capillary electrophoretic method was developed for simultaneous determination of mycophenolic acid (MPA) and its metabolites, acyl glucuronide (AcMPAG) and phenol glucuronide (MPAG), in human serum. The method utilized only running buffer in the separation, prior acidification of serum, and extraction with ethyl acetate. Separation was performed by capillary zone electrophoresis using 20 mM sodium acetate--acetic acid (pH 4.9) as running buffer, applied voltage of 15 kV, and UV detection at 217 nm. Each electrophoretic run was completed within 14 min. The optimized method demonstrated good performance concerning specificity, linearity (r > 0.998), sensitivity (limit of detection: for MPA, 0.10 μg/ml; for AcMPAG, 0.10 μg/ml; MPAG, 0.42 μg/ml), accuracy (87--108%) and precision (<9.3%). This method was successfully applied to measurements of MPA, AcMPAG, and MPAG in renal transplant patient samples and could be a useful alternative to HPLC-based methods. | |||||
書誌情報 |
Journal of Pharmaceutical and Biomedical Analysis 巻 47, 号 1, p. 201-206, 発行日 2008-05-12 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 07317085 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11533870 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 18262745 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jpba.2007.12.028 | |||||
権利 | ||||||
権利情報 | Copyright (c) 2007 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Pharmaceutical and Biomedical Analysis, 47(1), pp.201-206; 2008 |