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Breakdown of lung framework and an increase in pores of Kohn as initial events of emphysema and a cause of reduction in diffusing capacity
http://hdl.handle.net/10069/37287
http://hdl.handle.net/10069/372878b8cf99b-f7da-45c9-a0eb-c1565160326d
名前 / ファイル | ライセンス | アクション |
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IJCOPD11_2287.pdf (3.8 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-16 | |||||
タイトル | ||||||
タイトル | Breakdown of lung framework and an increase in pores of Kohn as initial events of emphysema and a cause of reduction in diffusing capacity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | COPD | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lung | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pathogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pathology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pulmonary function | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Fukuoka, Junya
× Fukuoka, Junya× Yoshikawa, Akira× Sato, Shuntaro× Tanaka, Tomonori× Hashisako, Mikiko× Kashima, Yukio× Tsuchiya, Tomoshi× Yamasaki, Naoya× Nagayasu, Takeshi× Yamamoto, Hiroshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: Pulmonary emphysema is the pathological prototype of chronic obstructive pulmonary disease and is also associated with other lung diseases. We considered that observation with different approaches may provide new insights for the pathogenesis of emphysema. Patients and methods: We reviewed tissue blocks of the lungs of 25 cases with/without emphysema and applied a three-dimensional observation method to the blocks. Based on the three-dimensional characteristics of the alveolar structure, we considered one face of the alveolar polyhedron as a structural unit of alveoli and called it a framework unit (FU). We categorized FUs based on their morphological characteristics and counted their number to evaluate the destructive changes in alveoli. We also evaluated the number and the area of pores of Kohn in FUs. We performed linear regression analysis to estimate the effect of these data on pulmonary function tests. Results: In multivariable regression analysis, a decrease in the number of FUs without an alveolar wall led to a significant decrease in the diffusing capacity of the lung for carbon monoxide (DLCO) and DLCO per unit alveolar volume, and an increase in the area of pores of Kohn had a significant effect on an increase in residual capacity. Conclusion: A breakdown in the lung framework and an increase in pores of Kohn are associated with a decrease in DLCO and DLCO per unit alveolar volume with/without emphysema. | |||||
書誌情報 |
International Journal of Chronic Obstructive Pulmonary Disease 巻 11, 号 1, p. 2287-2294, 発行日 2016-09-16 |
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出版者 | ||||||
出版者 | Dove Medical Press Ltd. | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 11782005 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2147/COPD.S114281 | |||||
権利 | ||||||
権利情報 | c 2016 Yoshikawa et al. | |||||
権利 | ||||||
権利情報 | This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License. By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Chronic Obstructive Pulmonary Disease, 11(1), pp.2287-2294; 2016 |