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Protective effect of porphyran isolated from discolored nori (Porphyra yezoensis) on lipopolysaccharide-induced endotoxin shock in mice
http://hdl.handle.net/10069/37292
http://hdl.handle.net/10069/37292d1383fcc-dce8-4f23-971f-cdda66867082
名前 / ファイル | ライセンス | アクション |
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IJBM93_1273.pdf (349.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2018-01-01 | |||||
タイトル | ||||||
タイトル | Protective effect of porphyran isolated from discolored nori (Porphyra yezoensis) on lipopolysaccharide-induced endotoxin shock in mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Porphyra yezoensis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | porphyran | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | LPS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endotoxin shock | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-inflammatory activity | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishiguchi, Tomoki
× Nishiguchi, Tomoki× Cho, Kichul× Isaka, Shogo× Ueno, Mikinori× Jin, Jun-O× Yamaguchi, Kenichi× Kim, Daekyung× Oda, Tatsuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Porphyran, a sulfated polysaccharide, isolated from discolored nori (Porphyra yezoensis) (dc-porphyran) and one fraction (F1) purified from dc-porphyran by DEAE-chromatography showed the protective effects on LPS-induced endotoxin shock in mice. Intraperitoneal (i.p.) treatment with dc-porphyran or F1 (100 mg/kg) 60 min prior to i.p. injection of LPS (30 mg/kg) completely protected mice from LPS lethality. At 10 mg/kg concentration, F1 demonstrated more protection than dc-porphyran. Intravenous (i.v.) challenge of LPS, even at 20 mg/kg, was more lethal than i.p. administration; i.v. injection of F1 (100 mg/kg) with LPS significantly improved the survival rate. However, i.v. dc-porphyran (100 mg/kg) produced an even lower survival rate than that of LPS alone. We examined pro-inflammatory mediators such as NO and TNF-α in serum. F1 significantly reduced the levels of these markers. Additionally, F1 significantly decreased the malondialdehyde level in the liver, a marker of oxidative stress, while dc-porphyran had almost no effect. Furthermore, F1 significantly decreased the production of TNF-α and NO in peritoneal exudate cells harvested from LPS-challenged mice, while dc-porphyran treatment showed a lesser decrease. Our results suggest that porphyran isolated from discolored nori, especially F1, is capable of suppressing LPS-induced endotoxin shock in vivo. | |||||
書誌情報 |
International Journal of Biological Macromolecules 巻 93, 号 Part A, p. 1273-1278, 発行日 2016-12 |
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出版者 | ||||||
出版者 | Elsevier B.V. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 01418130 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ijbiomac.2016.09.091 | |||||
権利 | ||||||
権利情報 | c 2016 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | International Journal of Biological Macromolecules, 93(Part A), pp.1273-1278; 2016 |