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Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease
http://hdl.handle.net/10069/37296
http://hdl.handle.net/10069/37296b0904252-04f9-4d74-aabe-33a3a5898ec7
名前 / ファイル | ライセンス | アクション |
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BPBul39_1646.pdf (481.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-16 | |||||
タイトル | ||||||
タイトル | Perturbed Calcineurin-NFAT Signaling Is Associated with the Development of Alzheimer’s Disease | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Alzheimer's disease | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Calcineurin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Down syndrome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Neprilysin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Nuclear factor of activated T cell (NFAT) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tau | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Asai, Masashi
× Asai, Masashi× Kinjo, Aimi× Kimura, Shoko× Mori, Ryotaro× Kawakubo, Takashi× Shirotani, Keiro× Yagishita, Sosuke× Maruyama, Kei× Iwata, Nobuhisa |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Down syndrome (DS), the most common genetic disorder, is caused by trisomy 21. DS is accompanied by heart defects, hearing and vision problems, obesity, leukemia, and other conditions, including Alzheimer's disease (AD). In comparison, most cancers are rare in people with DS. Overexpression of dual specificity tyrosine-phosphorylation-regulated kinase 1A and a regulator of calcineurin 1 located on chromosome 21 leads to excessive suppression of the calcineurin-nuclear factor of activated T cells (NFAT) signaling pathway, resulting in reduced expression of a critical angiogenic factor. However, it is unclear whether the calcineurin- NFAT signaling pathway is involved in AD pathology in DS patients. Here, we investigated the association between the calcineurin-NFAT signaling pathway and AD using neuronal cells. Short-term pharmacological stimulation decreased gene expression of tau and neprilysin, and long-term inhibition of the signaling pathway decreased that of amyloid precursor protein. Moreover, a calcineurin inhibitor, cyclosporine A, also decreased neprilysin activity, leading to increases in amyloid-β peptide levels. Taken together, our results suggest that a dysregulation in calcineurin-NFAT signaling may contribute to the early onset of AD in people with DS. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 39, 号 10, p. 1646-1652, 発行日 2016-10-01 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者別言語 | ||||||
Pharmaceutical Society of Japan | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13475215 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.b16-00350 | |||||
権利 | ||||||
権利情報 | c 2016 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin, 39(10), pp.1646-1652; 2016 |