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Change in Pharmacokinetics of Model Compounds with Different Elimination Processes in Rats during Hypothermia
http://hdl.handle.net/10069/15097
http://hdl.handle.net/10069/15097b1a2e58c-4f36-4991-a56e-9c62f92e29c4
名前 / ファイル | ライセンス | アクション |
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bpb_30_1763.pdf (150.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-03-05 | |||||
タイトル | ||||||
タイトル | Change in Pharmacokinetics of Model Compounds with Different Elimination Processes in Rats during Hypothermia | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypothermia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacokinetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | active transport | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glomerular filtration | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Okazaki, Madoka× Sakamoto, Ryuichi× Inaoka, Natsuko× Miyake, Hideaki× Fumoto, Shintaro× Nakamura, Junzo× Nakashima, Mikiro× Sasaki, Hitoshi× Kakumoto, Mikio× Sakaeda, Toshiyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We compared the pharmacokinetics of model compounds with different elimination processes between hypothermic and normothermic rats, to obtain basic information concerning drug therapy during hypothermia. Male Wistar rats were anesthetized with sodium pentobarbital and kept at temperatures of 37 °C (normothermic group) by heat lamp, and 32 °C or 28 °C (hypothermic group) by external cooling. We chose phenolsulfonphthalein (PSP), indocyanine green (ICG) and fluorescein isothiocyanate (FITC)-dextran (FD-4, Mw 4400) as model compounds to determine changes in clearance pathways during hypothermia therapy. The plasma concentrations of PSP as biliary, urinary and metabolic elimination type were increased significantly in the hypothermic group (32 °C, 28 °C) after i.v. administration at a dose of 1 mg, compared to the normothermic group (37 °C). Each PSP clearance (bile, urine and metabolites) in the hypothermic group was decreased, suggesting an influence of hypothermia on the active elimination process. The decreasing tendency was marked at a temperature of 28 °C. Moreover, the plasma concentrations of ICG as the biliary excretion type after i.v. administration to the hypothermic rats at a dose of 1 mg were higher with more than 50% decrease in the total body clearance compared to normothermic rats. On the other hand, there was almost no difference in the i.v. pharmacokinetics of FD-4 as the urinary excretion type between 37 °C and 32 °C. However, renal clearance of FD-4 was significantly decreased at a temperature of 28 °C. Accordingly, the change in pharmacokinetics of a drug in the hypothermic group could differ with the elimination processes. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 30, 号 9, p. 1763-1767, 発行日 2007-09 |
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出版者 | ||||||
出版者 | The Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00602100 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 17827736 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.30.1763 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1248/bpb.30.1763 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin v.30(9) p.1763-1767, 2007 |