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Beneficial Effect of Corni Fructus, a Constituent of Hachimi-jio-gan, on Advanced Glycation End-product-Mediated Renal Injury in Streptozotocin-Treated Diabetic Rats
http://hdl.handle.net/10069/15101
http://hdl.handle.net/10069/15101f42b2ee8-dca8-49cb-83d0-70032f87dd09
名前 / ファイル | ライセンス | アクション |
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bpb_30_520.pdf (339.8 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2008-03-05 | |||||
タイトル | ||||||
タイトル | Beneficial Effect of Corni Fructus, a Constituent of Hachimi-jio-gan, on Advanced Glycation End-product-Mediated Renal Injury in Streptozotocin-Treated Diabetic Rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Corni Fructus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | aminoguanidine | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | advanced glycation end-product | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | renal damage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | streptozotocin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamabe, Noriko
× Yamabe, Noriko× Kang, Ki Sung× Goto, Eiko× Tanaka, Takashi× Yokozawa, Takako |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Previous investigations have demonstrated that Hachimi-jio-gan, a Chinese prescription consisting of eight crude drugs, has a therapeutic potential in diabetes and diabetic nephropathy, using these model rats. To add to these findings, we performed this study to assess whether one of the crude drugs, Corni Fructus (Cornus officinalis SIEB. et ZUCC.), had an effect on streptozotocin-induced diabetic rats as a major active constituent, compared with an inhibitor of advanced glycation end-product (AGE) formation, aminoguanidine. Diabetic rats were orally administrated Corni Fructus extract (50, 100, 200 mg/kg body weight/d) or aminoguanidine (100 mg/kg body weight/d). Treatment with Corni Fructus for 10 d suppressed hyperglycemia, proteinuria, renal AGE formation, and related protein expressions, i.e., receptor for AGEs, nuclear factor-κB, transforming growth factor-β1, and Nε-(carboxymethyl)lysine, in the same way as with aminoguanidine. However, improvement of renal function, shown via serum creatinine (Cr) and Cr clearance, was superior to aminoguanidine treatment. In conclusion, the present study supported the hypothesis that Corni Fructus plays an important role against diabetic pathogenesis, i.e., reducing glucose toxicities, up-regulating renal function, and consequently ameliorating glycation-associated renal damage; thus, this study may provide a new recognition of crude drugs to clarify the mechanisms of Chinese prescriptions. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 30, 号 3, p. 520-526, 発行日 2007-03 |
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出版者 | ||||||
出版者 | The Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00602100 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 17329849 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.30.520 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1248/bpb.30.520 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin v.30(3) p.520-526, 2007 |