WEKO3
アイテム
{"_buckets": {"deposit": "662cd0c2-b725-4803-b1ce-ef886783e90f"}, "_deposit": {"created_by": 2, "id": "2129", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "2129"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00002129", "sets": ["36"]}, "author_link": ["9826", "9822", "9821", "9824", "9825", "9823"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2016-10-11", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "31", "bibliographicVolumeNumber": "44", "bibliographic_titles": [{"bibliographic_title": "Tropical Medicine and Health"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Background: Ticks have been long known as vectors of various pathogens, some of which can cause high fatality rates among infected individuals. Our enhanced tick surveillance around Nagasaki, Japan, led to the isolation and identification of a new strain of a recently identified Orbivirus, Muko virus (MUV). The orbiviruses have a wide host range, including humans, and is related to a spectrum of clinical outcomes. However, the zoonotic potential of some members of the genus, although reported, were not clearly elucidated. Hence, it is imperative to characterize newly isolated orbiviruses and investigate its ability to endanger public health. Methods: In this study, we explored the in vivo pathogenicity of a newly isolated MUV strain (MUV-Hay) using a mouse model and demonstrated its growth kinetics in human-derived cells. Results: Our results showed the ability of MUV-Hay to propagate in human neuronal and renal cells with some cytopathic effect. Furthermore, intracerebral inoculation of our new isolate caused high mortality in adult A129 mice. Conclusion: Our study provided a first step to experimentally test the hypothesis, that MUV can replicate and produce cytopathic effect in human cells and demonstrate virulence in adult mice.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Tropical Medicine and Health, 44, 31; 2016", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "日本熱帯医学会"}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1186/s41182-016-0032-7", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "c The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated."}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "13494147", "subitem_source_identifier_type": "ISSN"}]}, "item_2_text_62": {"attribute_name": "出版者別言語", "attribute_value_mlt": [{"subitem_text_value": "Japanese Society of Tropical Medicine"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Ulanday, Gianne Eduard L."}], "nameIdentifiers": [{"nameIdentifier": "9821", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shimada, Satoshi"}], "nameIdentifiers": [{"nameIdentifier": "9822", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Myat, Ngwe Tun Mya"}], "nameIdentifiers": [{"nameIdentifier": "9823", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nabeshima, Takeshi"}], "nameIdentifiers": [{"nameIdentifier": "9824", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Morita, Kouichi"}], "nameIdentifiers": [{"nameIdentifier": "9825", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayasaka, Daisuke"}], "nameIdentifiers": [{"nameIdentifier": "9826", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-21"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "TMH44_31.pdf", "filesize": [{"value": "836.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 836500.0, "url": {"label": "TMH44_31.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/2129/files/TMH44_31.pdf"}, "version_id": "dac6e904-1820-474c-bb29-4e1b4abaf1fa"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Human-derived cells", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Mouse model", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Muko virus", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tick-borne virus", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pathogenic potential and growth kinetics of Muko virus in mice and human-derived cells", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pathogenic potential and growth kinetics of Muko virus in mice and human-derived cells"}]}, "item_type_id": "2", "owner": "2", "path": ["36"], "permalink_uri": "http://hdl.handle.net/10069/37325", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-05-19"}, "publish_date": "2017-05-19", "publish_status": "0", "recid": "2129", "relation": {}, "relation_version_is_last": true, "title": ["Pathogenic potential and growth kinetics of Muko virus in mice and human-derived cells"], "weko_shared_id": -1}
Pathogenic potential and growth kinetics of Muko virus in mice and human-derived cells
http://hdl.handle.net/10069/37325
http://hdl.handle.net/10069/373255e890a78-4d71-4504-a72a-0b629f404b16
名前 / ファイル | ライセンス | アクション |
---|---|---|
TMH44_31.pdf (836.5 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2017-05-19 | |||||
タイトル | ||||||
タイトル | Pathogenic potential and growth kinetics of Muko virus in mice and human-derived cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Human-derived cells | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mouse model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Muko virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Tick-borne virus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Ulanday, Gianne Eduard L.
× Ulanday, Gianne Eduard L.× Shimada, Satoshi× Myat, Ngwe Tun Mya× Nabeshima, Takeshi× Morita, Kouichi× Hayasaka, Daisuke |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Ticks have been long known as vectors of various pathogens, some of which can cause high fatality rates among infected individuals. Our enhanced tick surveillance around Nagasaki, Japan, led to the isolation and identification of a new strain of a recently identified Orbivirus, Muko virus (MUV). The orbiviruses have a wide host range, including humans, and is related to a spectrum of clinical outcomes. However, the zoonotic potential of some members of the genus, although reported, were not clearly elucidated. Hence, it is imperative to characterize newly isolated orbiviruses and investigate its ability to endanger public health. Methods: In this study, we explored the in vivo pathogenicity of a newly isolated MUV strain (MUV-Hay) using a mouse model and demonstrated its growth kinetics in human-derived cells. Results: Our results showed the ability of MUV-Hay to propagate in human neuronal and renal cells with some cytopathic effect. Furthermore, intracerebral inoculation of our new isolate caused high mortality in adult A129 mice. Conclusion: Our study provided a first step to experimentally test the hypothesis, that MUV can replicate and produce cytopathic effect in human cells and demonstrate virulence in adult mice. | |||||
書誌情報 |
Tropical Medicine and Health 巻 44, p. 31, 発行日 2016-10-11 |
|||||
出版者 | ||||||
出版者 | 日本熱帯医学会 | |||||
出版者別言語 | ||||||
Japanese Society of Tropical Medicine | ||||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13494147 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s41182-016-0032-7 | |||||
権利 | ||||||
権利情報 | c The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Tropical Medicine and Health, 44, 31; 2016 |