WEKO3
アイテム
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Pathological significance and prognostic implications of heme oxygenase 1 expression in non?muscle?invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX?2
http://hdl.handle.net/10069/37360
http://hdl.handle.net/10069/37360d34b2994-d159-4866-a62e-84c5a31aad65
名前 / ファイル | ライセンス | アクション |
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OncLet13_275.pdf (680.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-05-25 | |||||
タイトル | ||||||
タイトル | Pathological significance and prognostic implications of heme oxygenase 1 expression in non?muscle?invasive bladder cancer: Correlation with cell proliferation, angiogenesis, lymphangiogenesis and expression of VEGFs and COX?2 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Angiogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell proliferation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cyclooxygenase-2 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Heme oxygenase 1 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lymphangiogenesis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Non-muscle-invasive bladder cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Vascular endothelial growth factor | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Matsuo, Tomohiro
× Matsuo, Tomohiro× Miyata, Yasuyoshi× Mitsunari, Kensuke× Yasuda, Takuji× Ohba, Kojiro× Sakai, Hideki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Heme oxygenase 1 (HO-1) is a stress-response protein and its expression is associated with malignant potential and poor prognosis in several types of cancer. The present study investigated the association between HO-1 expression levels and the pathological features, clinical outcomes and other associated factors in patients with non-muscle-invasive bladder cancer (NMIBC). HO-1 expression was evaluated using immunohistochemistry in 147 formalin-fixed tissue specimens. The proliferation index, microvessel density, lymph vessel density and expression of cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF)-A, -C, and-D were also investigated. Correlations among variables were analyzed by multivariate analysis. Survival was assessed using Kaplan-Meier survival curves and multivariate statistics. HO-1 expression levels in high-grade and pT1 tumors were significantly higher compared with low-grade and pTa tumors, and were correlated with the proliferation index (P<0.001), lymph vessel density (P=0.021) and COX-2 expression levels (P=0.003). The proliferation index and COX-2 expression levels were also identified as independent contributing factors in multivariate models. Kaplan-Meier survival curves associated HO-1 expression with a poor prognosis in metastasis-free (P=0.047) and cause-specific survival (P=0.017), but not with urinary tract recurrence (P=0.231). Furthermore, HO-1 expression was identified by multivariate analysis to be a significant predictor for cause-specific survival (hazard ratio, 4.08; 95% confidence interval, 1.06-15.66; P=0.004). HO-1 has an important role in the malignant aggressiveness of NMIBC and its expression is associated with cause-specific survival. HO-1-associated activities are regulated by cancer cell proliferation, lymphangiogenesis and COX-2. The results suggest that HO-1 may be a potential therapeutic target and a useful predictive prognostic factor in patients with NMIBC. | |||||
書誌情報 |
Oncology Letters 巻 13, 号 1, p. 275-280, 発行日 2016-11-22 |
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出版者 | ||||||
出版者 | Spandidos Publications | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17921074 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 17921082 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3892/ol.2016.5416 | |||||
権利 | ||||||
権利情報 | c 2016, Spandidos Publications. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oncology Letters, 13(1), pp.275-280; 2016 |