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Four groups of experiments were performed in the present study as follow; (1) Intact dogs (2) Carbon tetrachloride intoxicated dogs (CCl4-dogs) (3) Chloroform intoxicated dogs (CHCl3-dogs) (4) Dogs with obstructive jaundice due to common bile duct ligation (Jaundice dogs) In intact dogs, the reduction rate of catecholamine in the liver 1 minute after the administration of adrenaline and noradrenaline was over 70.1% for adrenaline and 56.1% for noradrenaline. Then the reduction rate of adrenaline was higher than that of noradrenaline. The content of catecholamine was markedly reduced at 3 minutes, and the reduction rate was less at 3 minutes than at 1 minute. In dogs with severe damaged liver such as CCl4-dogs and CHCl3-dogs, the reduction rate of catecholamine in the liver was lowered markedly about 10 to 30%, and a highly significant difference was found between this group and intact group. In jaundice dogs with the moderate damaged liver, the figure was between the above two groups. 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Studies on the Elimination of Catecholamine in the Dog's Liver in Vivo after the Administration of Adrenaline and Noradrenaline
http://hdl.handle.net/10069/15540
http://hdl.handle.net/10069/15540372b9264-99a2-4bfe-98af-0d540d7a5f21
名前 / ファイル | ライセンス | アクション |
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acta13_01_07_t.pdf (1.6 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-10 | |||||
タイトル | ||||||
タイトル | Studies on the Elimination of Catecholamine in the Dog's Liver in Vivo after the Administration of Adrenaline and Noradrenaline | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Noritomi, Satoru
× Noritomi, Satoru |
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著者別名 | ||||||
姓名 | 乗富, 智 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In dogs anesthetized with sodium pentobarbital, adrenaline and noradrenaline in the portal and hepatic vein were estimated by using a fluorimetric method after the administration of mixed each 100μg/kg of adrenaline and noradrenaline. Four groups of experiments were performed in the present study as follow; (1) Intact dogs (2) Carbon tetrachloride intoxicated dogs (CCl4-dogs) (3) Chloroform intoxicated dogs (CHCl3-dogs) (4) Dogs with obstructive jaundice due to common bile duct ligation (Jaundice dogs) In intact dogs, the reduction rate of catecholamine in the liver 1 minute after the administration of adrenaline and noradrenaline was over 70.1% for adrenaline and 56.1% for noradrenaline. Then the reduction rate of adrenaline was higher than that of noradrenaline. The content of catecholamine was markedly reduced at 3 minutes, and the reduction rate was less at 3 minutes than at 1 minute. In dogs with severe damaged liver such as CCl4-dogs and CHCl3-dogs, the reduction rate of catecholamine in the liver was lowered markedly about 10 to 30%, and a highly significant difference was found between this group and intact group. In jaundice dogs with the moderate damaged liver, the figure was between the above two groups. Levels of S-GOT and S-GPT were inversely proportional to the reduction rate of adrenaline and noradrenaline in the liver. In intact dogs the glucose from the liver began to release between 1 and 3 minutes after the catecholamine infusion and showed as peak at 7 minutes. On the other hand, in CCl4-dogs and CHCl3-dogs the glucose output from the liver was not occured. In jaundice dogs the glucose output from the liver was found, but less than in intact dogs. It is concluded that the liver would reduce a large amount of adrenaline and noradrenaline and the reduction rate would vary in proportion to the degree of damage to the liver. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 13, 号 1-2, p. 94-113, 発行日 1968-10-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00094-P00113 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1968, 13(1-2), p.94-113 |