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Ontogenic Development of Thymocyte in Normal and Bis-diamine Treated Rats -Immuno- and Enzymo-histochemical Studies-
http://hdl.handle.net/10069/15673
http://hdl.handle.net/10069/1567338ec71ba-4559-4a69-ac7b-295bf2aad4bb
名前 / ファイル | ライセンス | アクション |
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acta30_01_13_t.pdf (3.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-10 | |||||
タイトル | ||||||
タイトル | Ontogenic Development of Thymocyte in Normal and Bis-diamine Treated Rats -Immuno- and Enzymo-histochemical Studies- | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Jyubashi, Tohru
× Jyubashi, Tohru |
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著者別名 | ||||||
姓名 | 重橋, 亨 | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The ontogenic development of rat thymocytes was studied immunohistochemically for the expression of cell surface antigens and enzymohistochemically for the activity of lysosomal enzymes in both normal and bis-diamine-induced hypoplastic thymuses. In normal thymus, W 3/13 antigen was expressed first on thymocytes on gestation day 16, and followed simultaneously by W 3/25, MRC OX8 and MRC OX7 antigens on gestation day 18. The thymocytes bearing these antigens increased rapidly in number during the late fetal life, and the thymocytes with the same antigenic profiles as mature peripheral T cells seemed to occur within the medulla from day 20 of gestation when the cortex and medulla could be distinguished. A possible maturation pathway of T cell surface antigens within the thymus is discussed. Positive thymocytes for AcP, B-G and ANAE activities were demonstrated in varying frequency in all fetal thymuses examined, and they were distributed in much higher frequency in the medulla than in the cortex after birth. The data suggests that the presence per se of AcP, B-G and ANAE activities is independent of ontogenic thymocyte differentiation. Significantly hypoplastic thymuses were induced by treatment with bis-diamine in rat. These thymuses showed a retardation in ontogenic differentiation of thymocyte surface antigens, which was well correlated with the delay in morphologic development of thymuses. Furthermore, the immunopathological correlation between the bis-diamine-induced malformation complex in rat and the DIGEORGE's syndrome in man is discussed. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 30, 号 1-3, p. 119-138, 発行日 1985-10-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00119-P00138 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1985, 30(1-3), p.119-138 |