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Morphogenesis of Aortico-pulmonary Septation Anomaly Induced by Bis-diamine Treatment Special reference to vimentin, desmin and fibronectin immunoreactivities
http://hdl.handle.net/10069/15760
http://hdl.handle.net/10069/157609490ed0d-a3ce-46a0-a6a8-f518decd7bb6
名前 / ファイル | ライセンス | アクション |
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acta34_02_08_t.pdf (12.2 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Morphogenesis of Aortico-pulmonary Septation Anomaly Induced by Bis-diamine Treatment Special reference to vimentin, desmin and fibronectin immunoreactivities | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kose, Noriyuki
× Kose, Noriyuki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In order to clarify the morphogenesis of the A-P septum, the conotruncal septum, the myocardial sheath and the smooth muscle cells of the great arteries in the normal hearts and bis-diamine induced cardiovascular anomalies, an immunohistochemical technique using the antibodies for vimentin, desmin and fibronectin was applied. Morphological and immunohistochemical changes in the treated hearts were as follows : (1) the A-P septum which was hypoplastic appeared later than in the normal hearts ; (2) retraction of the myocardial sheath was delayed compared with the normal hearts ; (3) switching from vimentin to desmin in the muscles of the atria and ventricles caused a delay of one day behind that of the normal hearts ; (4) vimentin immuno-reactivity in the smooth muscle cells of the pulmonary trunk was weaker than that of the aorta, and (5) weak reactivity of fibronectin occurred concomitant with weak vimentin reactivity. It is concluded that bisdiamine may induce the morphological anomalies of the A-P septation by inhibiting the production or perturbing the migration of neural crest cells which have been a precursor of the mesenchyme in the anlage of the A-P septum, subsequently by either inhibiting production or changing the nature of extracellular matrix, or by affecting the coordination of intermediate filaments. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 34, 号 2-4, p. 35-52, 発行日 1989-12-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00035-P00052 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1989, 34(2-4), p.35-52 |