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Effect of Hyperthermia with Interferon on Malignant Cell Growth and Cell Cycle
http://hdl.handle.net/10069/15786
http://hdl.handle.net/10069/1578610f46663-7e02-4173-9db3-12286441fc9c
名前 / ファイル | ライセンス | アクション |
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acta34_02_34_t.pdf (652.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Effect of Hyperthermia with Interferon on Malignant Cell Growth and Cell Cycle | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Satou, Tetuya
× Satou, Tetuya |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Combined therapy of hyperthermia with interferon-β (rHuIFN-β) for carcinoma using HeLa cells was evaluated by in vitro study. Inhibitory effect on cell growth curve was observed in thetreatment of rHuIFN-β and/or hyperthermia alone. On the other hand, combined treatment much more promoted the inhibitory effect rather than single method. From the standpoint of the cell cycle on the basis of a result of flow cytometry study, a reduction of the G1-phase cells population and accumulation of the S-phase cells were significantly noted. Furthermore, the addition of hyperthermia significan t-ly recruited the S-phase cells. When administering rHuIFN-β, the activity of DNA polymerase α was reduced and that of DNA polymerase β was inversely increased. While hyperthermia was added, both the levels of DNA polymerise α and β activities were decreased. It was different patterns in terms of enzymatic activities regarding accumulation of the S-phase cells. In conclusion, in order to get the cytocidal effect on the HeLa cells, the ideal timing applying combined treatment of HuIFN-β with hyperthermia is that HuIFN-β should be first given, thereafter hyperthermia is applied so as to adjust to the S-phas e of the cell cycle which is greatly sensitive to hyperthermia. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 34, 号 2-4, p. 191-198, 発行日 1989-12-09 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00191-P00198 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1989, 34(2-4), p.191-198 |