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A Study on Enhancement of Hyperthermochemotherapy in the Presence of Buthionine Sulfoximine (BSO)
http://hdl.handle.net/10069/15843
http://hdl.handle.net/10069/15843dda37ba1-88af-4e46-a136-54cb2e9413a9
名前 / ファイル | ライセンス | アクション |
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acta35_01_43_t.pdf (559.6 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | A Study on Enhancement of Hyperthermochemotherapy in the Presence of Buthionine Sulfoximine (BSO) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kunisaki, Tadaomi
× Kunisaki, Tadaomi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of this study was enhancement of the effect of hyperthermia which is a part of the multidisciplinary treatments for carcinomas. Many physicians suffered from practical difficulty in keeping the uniformity of 43℃ in the deep organs. Buthionine sulfoximine (BSO) is a specific inhibitor of glutathione (GSH) synthesis, and suppress GSH activity which is related to the repair process of cell damage. In this study, colony formation was tested using HeLa cells on the condition of one hour heating in the presence of 1mM BSO which is suitable for clinical application. The concentration of 0.08ug cis DDP was used, corresponding to LD25. Colony formation was reduced to 45% and 19% at 40℃ and 41℃ in combination cis DDP in the presence of BSO. From the analysis of flowcytometry inhibition of accumulation in G2M phase was observed at 12 and 24 hours exposing to 41℃ and 42℃ heating in the presence of BSO. The cells were increased in number for 24 hours at 41ーC heating on the basis of analysis of cell growth curve. Atotal of GSH were reduced to 2.4% in the presence of BSO as compared with 41℃ heating alone. It is concluded that BSO helps escape repair process from thermal cytotoxicity and BSO plays an important role in promoting the effect of chemohyperthermia for the treatment, of carcinomas. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 35, 号 1-4, p. 209-215, 発行日 1990-12-14 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00209-P00215 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1990, 35(1-4), p.209-215 |