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The Effect of Epidermal Growth Factor, Basic Fibroblast Growth Factor, Transforming Growth Factor-β, and Insulin on the DNA Synthesis of Renal Cell Carcinoma Cell Lines.
http://hdl.handle.net/10069/15866
http://hdl.handle.net/10069/158663b825b88-1fd4-46c6-9f1a-7258462e1413
名前 / ファイル | ライセンス | アクション |
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acta36_01_11_t.pdf (324.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | The Effect of Epidermal Growth Factor, Basic Fibroblast Growth Factor, Transforming Growth Factor-β, and Insulin on the DNA Synthesis of Renal Cell Carcinoma Cell Lines. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Nishimura, Naoki
× Nishimura, Naoki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this experiment, the effect of various growth factors (epidermal growth factor, basic fibroblast growth factor, transforming growth factor-β and insulin) on the DNA synthesis of three renal cell carcinoma cell lines (ACHN, VMRC-RCW, NT) has been investigated in a serum free condition. These growth factors atimulated the DNA synthesis of all renal cell carcinoma cell lines dose-dependently. Transforming growth factor-β, a known growth inhibitor for renal tubular cells, stimulated the DNA synthesis of renal cell carcinoma cells. The conditioned medium (which did not include any serum) contained very litle autocrine growth factor for renal cell carcinoma cell itself. These results suggest that paracrine growth factors are mostly related to the growth of renal cell carcinoma cells than autocrine growth factor. The renal cell carcinoma cells, which are the transformed form of renal tubular cells and due to this transformed character, TGF-β which is basically a growth inhibitor for tubular cell but stimulates the renal cell carcinoma cell. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 36, 号 1-4, p. 47-51, 発行日 1991-12-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00047-P00051 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1991, 36(1-4), p.47-51 |