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Effect of 1-arginine HC1 and OK-432 on the inhibition of Lung Metastasis in Mice
http://hdl.handle.net/10069/15879
http://hdl.handle.net/10069/15879a398a9dc-412e-4113-a447-f151b1b97de4
名前 / ファイル | ライセンス | アクション |
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acta36_01_24_t.pdf (1.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Effect of 1-arginine HC1 and OK-432 on the inhibition of Lung Metastasis in Mice | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Mine, Yoshikazu
× Mine, Yoshikazu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | To investigate the effect of OK-432 and 1-arginine HC1 on the artificial metastases in lung, mice were injected mouse colon carcinoma, colon 26 cells(1×10 6). Pulmonary nodules produced by the i. v. injection of 1×10 6 colon tumor 26 cells into a caudal vein were evaluated after 3 weeks. OK-432, 1KE/mouse, was administered by the i. v. injection three times on day 0, 2, 4 after the tumor injection. L-arginine HC1, 50mg/mouse, was given by the i. p. injection 6-7 times on day 0, 1, 2,3,4,5,6. IV administration of OK-432 led to a significant suppression of lung metastases formation in comparison to salin-injected animals. Furthermore, OK-432 and i. p. administration of 1-arginine HC1 let to a considerable, synergisticaly retardation of tumor metastasis. The suppressive effect of OK-432 and 1-arginine HC1 on the artificial lung metastases may be due to its activation of the immunologic system. And this work suggest that OK-432 and 1-arginine HC1 enhanced the phagocytic activity of macrophages in vivo. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 36, 号 1-4, p. 128-135, 発行日 1991-12-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00128-P00135 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1991, 36(1-4), p.128-135 |