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The Role of Laminin on Cultured Human Glioma Cell Proliferation and Metastasis in Nude Mice and Rats
http://hdl.handle.net/10069/15930
http://hdl.handle.net/10069/159301481c914-8bbd-40a8-b29a-2497e1ea8fa5
名前 / ファイル | ライセンス | アクション |
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acta38_02_27_t.pdf (619.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | The Role of Laminin on Cultured Human Glioma Cell Proliferation and Metastasis in Nude Mice and Rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Zhong, Xue-Yun
× Zhong, Xue-Yun× Senba, Masachika× Chen, Yun-Xian× Nishigami, Takashi× Miyaji, Hideki |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | It is difficult to propose simple idea in which cell adhesion molecules can he related to tumor growth and metastasis. The integrins function as extracellular matrix receptors binding to such proteins as collagen, laminin, and fibronectin. In this study, the cell culture of human glioma cells were xenografted to nude mice and rats associated with laminin injection, resulting in tumor growth and metastasis in the large amount of laminin group. In nude mouse experiment, cultured glioma cells were xenografted in the back of cutaneous with 10μg and 100μg laminin. The tumor lump of the 100μg laminin group grew faster and larger than the 10μg laminin group. In nude rat experiment, cultured glioma cells were xenografted intravascularly in the tail with l0μg and 100μg laminin. Of the 6 cases, 4 (66.7%) showed metastasis in the lungs after 2 weeks in the 100μg laminin group. However, metastasis was not detected in 10μg laminin group. These results suggest that quantities of laminin may play an important role in tumor growth and metastasis. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 38, 号 2-4, p. 164-167, 発行日 1993-12-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00164-P00167 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1993, 38(2-4), p.164-167 |