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Neutrophil Activation in Ischemia-reperfusion Injury of the Lung
http://hdl.handle.net/10069/15942
http://hdl.handle.net/10069/159423269621c-955b-46b7-bcd9-472cf50ab03d
名前 / ファイル | ライセンス | アクション |
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acta38_02_39_t.pdf (766.2 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2008-03-13 | |||||
タイトル | ||||||
タイトル | Neutrophil Activation in Ischemia-reperfusion Injury of the Lung | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Takahashi, Takao
× Takahashi, Takao |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Activated neutrophils and oxygen free radicals have been implicated in the pathogenesis of lung injury associated with ischemia reperfusion. This study tests whether postischemic reperfusion in the lung activates neutrophils and whether superoxide dismutase (SOD) could block this event. Ten anesthetized mongrel dogs underwent three hours of warm ischemia to their left lung followed by 120 minutes of reperfusion. Pulmonary venous blood was assayed for neutrophil hydrogen peroxide production and plasma thiobarbituric acid reactive materials (TBARM) immediately before (baseline) and during reperfusion. Neutrophil hydrogen peroxide production, as assayed flow cytometrically by dichlorofluorescein oxidation, was elevated significantly to 123.9 ± 21.1% of baseline at 30 minutes of reperfusion. Plasma TBARM was elevated significantly to 124.2 ± 23.6% of baseline at 60 minutes after reperfusion. However, in six animals which recieved human recombinant SOD (intravenously, 35000U/kg) at the onset of reflow, neither neutrophil hydrogen peroxide production nor plasma TBARM changed during reperfusion. Treatment with SOD was also associated with significant improvement in the recovery of lung function. In conclusion, these data demonstrate that post-ischemic lung reperfusion enhances neutrophil hydrogen peroxide and free radical production, and can be blocked by intravenous SOD. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 38, 号 2-4, p. 216-221, 発行日 1993-12-25 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
sortkey | ||||||
P00216-P00221 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 1993, 38(2-4), p.216-221 |