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T-cell Receptor Assay and Reticulocyte-Micronuclei Assay as Biological Dosimeters for Ionizing Radiation in Humans
http://hdl.handle.net/10069/9306
http://hdl.handle.net/10069/93063b9a6903-2a4b-4692-86f7-bde4c8766850
名前 / ファイル | ライセンス | アクション |
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acta50_s1_15.pdf (941.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-11-02 | |||||
タイトル | ||||||
タイトル | T-cell Receptor Assay and Reticulocyte-Micronuclei Assay as Biological Dosimeters for Ionizing Radiation in Humans | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | T-cellreceptor | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Micronucleus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | CD71positivereticulocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Transferrinpositivereticulocyte | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mutation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Radiation | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Vershenya, Stanislav
× Vershenya, Stanislav× Biko, Johannes× Lorenz, Reinhard× Reiners, Christoph× Stopper, Helga× Grawe, Jan× Hempel, Klaus |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In radiation accidents, biological methods are used for dosimetry if the radiation dose could not be measured by physical means. The knowledge of individual dose is a prerequisite for planning medical treatment and for health risk evaluations. In this paper we represent the summary of biodosimetrical methods used in our laboratory in the patients treated with radioiodine for thyroid cancer. The dose-response relationship was measured by the flow cytometry-based micronucleus assay in transferrin receptor positive reticulocytes (MN-Tf-Ret assay) and by the T-cell receptor (TCR) assay in CD4 lymphocytes. Compared to our previous works, the database for TCR assay was significantly improved, and two groups of thyroid cancer patients (from Belarus and Germany) were studied. In the MN-Tf-Ret test, mutant frequency increased proportionally with the radiation dose, whereas in the TCR-test the dose relationship could be described by an exponential equation which takes into account the limited lifespan of TCR mutants. Finally, these assays are compared with other biodosimetrical assays used in patients treated with radioiodine. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 50, 号 supl.1, p. 15-21, 発行日 2005-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.S15 | |||||
sortkey | ||||||
P00015-P00021 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2005, 50(supl.1), p.15-21 |