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Evidence for Induction of DNA Double Strand Breaks in the Bystander Response to Targeted Soft X-Rays in Repair Deficient CHO Cells
http://hdl.handle.net/10069/9315
http://hdl.handle.net/10069/9315bf75970f-0259-4c47-a0b0-405bfde36cdc
名前 / ファイル | ライセンス | アクション |
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acta50_s1_69.pdf (438.5 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-11-02 | |||||
タイトル | ||||||
タイトル | Evidence for Induction of DNA Double Strand Breaks in the Bystander Response to Targeted Soft X-Rays in Repair Deficient CHO Cells | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bystandereffect | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNArepair | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | DNAdoublestrandbreak | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Basedamage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | SoftX-ray | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Microbeam | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Kashino, Genro
× Kashino, Genro× Suzuki, Keiji× M.Prise, Kevin× Schettino, Giuseppe× Folkard, Melvyn× Vojnovic, Borivoj× D.Michael, Barry× Kodama, Seiji× Matsuda, Naoki× Watanabe, Masami |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Evidence is accumulating that irradiated cells produce some signals which interact with non-exposed cells in the same population. Here, we analysed the mechanism of such a bystander effect from targeted cells to non-targeted cells. Firstly, in order to investigate the bystander effect in CHO cell lines we irradiated a single cell within a population and scored the formation of micronuclei. When a single nucleus in the population, of double strand break repair deficient xrs5 cells, was targeted with 1Gy of Al-K soft X-rays, elevated numbers of micronuclei were induced in the neighbouring unirradiated cells. The induction of micronuclei was also observed when conditioned medium was transferred from irradiated to non-irradiated xrs5 cells. These results suggest that DNA double strand breaks are caused by factors secreted in the medium from irradiated cells. To clarify the involvements of radical species in the bystander response, cells were treated with 0.5%DMSO 1 hour before irradiation and then bystander effects were estimated in xrs5 cells. The results showed clearly that DMSO treatment during X-irradiation suppress the induction of micronuclei in bystander xrs5 cells, when conditioned medium was transferred from irradiated xrs5 cells. Therefore, it is suggested that radical species induced by ionizing radiation are important for producing bystander signals. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 50, 号 supl.1, p. 69-71, 発行日 2005-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/50.S69 | |||||
sortkey | ||||||
P00069-P00071 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2005, 50(supl.1), p.69-71 |