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HIV- and HHV-8-negative Primary Effusion Lymphoma Harboring the Dual Rearrangement of Antigen Receptor Genes and a Translocation of bcl-6
http://hdl.handle.net/10069/9364
http://hdl.handle.net/10069/9364373fff31-b507-46c9-bad8-eb890f9366ba
名前 / ファイル | ライセンス | アクション |
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acta51_02_73.pdf (900.4 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2007-11-02 | |||||
タイトル | ||||||
タイトル | HIV- and HHV-8-negative Primary Effusion Lymphoma Harboring the Dual Rearrangement of Antigen Receptor Genes and a Translocation of bcl-6 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | PEL | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bcl-6/IgHtranslocation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HIV | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HHV-8 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Chen, Jiann-I
× Chen, Jiann-I× Uemura, Akiko× Mori, Sayaka× Tsuruda, Kazuto× Hasegawa, Hiroo× Hirakata, Yoichi× Sugahara, Kazuyuki× Yamada, Yasuaki× Kamihira, Shimeru |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Primary effusion lymphoma (PEL) is a rare type of lymphoma occurring in HIV-seropositive persons. Since the tumor cells frequently harbor human herpes virus (HHV)-8 DNA, the virus is thought to be causative. We here report an instructive case of PEL in an HIV-seronegative elderly. The neoplastic cells in the fluid showed unusual morphology with multi-lobulated nuclei. They expressed CD19, CD20, CD79a and SmIgD/Mκ, but not CD3, CD30 or CD23. The IgH gene was clonally rearranged based on the results of Southern blotting and PCR for CDR3. In addition to the IgH clonality, the TCRγ-chain gene was also in the clonal rearrangements. Neither HHV8 nor EBV was detected in the cells. The bcl-6 and IgH chimeric transcripts were evident. Conclusively, our case suggests the following two points: first, the bcl-6/IgH translocation may be associated with the pathogenesis of unusual PEL without HIV or HHV-8; and second, unusual PEL may be an extra-nodal spectrum of diffuse large-cell lymphoma with neoplastic cells harboring the bcl-6/IgH translocation and dual rearrangements of antigen receptor genes. | |||||
書誌情報 |
Acta medica Nagasakiensia 巻 51, 号 2, p. 73-77, 発行日 2006-06 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00016055 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00508430 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://joi.jlc.jst.go.jp/JST.JSTAGE/amn/51.73 | |||||
sortkey | ||||||
P00073-P00077 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Acta medica Nagasakiensia. 2006, 51(2), p.73-77 |