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Histopathological Findings of Lung with A/H1N1pdm09 Infection-Associated Acute Respiratory Distress Syndrome in the Post-Pandemic Season
http://hdl.handle.net/10069/37486
http://hdl.handle.net/10069/3748626c81fa1-2443-4a1c-9c97-3003196615c7
名前 / ファイル | ライセンス | アクション |
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JID70_197.pdf (419.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-06-05 | |||||
タイトル | ||||||
タイトル | Histopathological Findings of Lung with A/H1N1pdm09 Infection-Associated Acute Respiratory Distress Syndrome in the Post-Pandemic Season | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | A/H1N1pdm09 | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | ARDS | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Influenza virus | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pneumonia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sepsis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Hayashi, Kentaro
× Hayashi, Kentaro× Yoshida, Hiroshi× Sato, Yuko× Tobiume, Minoru× Suzuki, Yoshio× Ariyoshi, Koya× Hasegawa, Hideki× Nakajima, Noriko |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We herein report the pulmonary histopathological findings of an autopsy case of postpandemic season A/H1N1pdm09 infection-associated acute respiratory distress syndrome (ARDS). The lung histology predominantly exhibited findings indicative of the exudative phase of diffuse alveolar damage, with similar inflammation severity observed in all sections. Furthermore, the lung sections only showed a few A/H1N1pdm09 antigen-positive cells along with a low viral RNA copy number. The sequence of the viral hemagglutinin receptor binding site identified a preference for a-2,6 linked sialic acid, suggesting low alveolar epithelial cell infectivity. The pathological findings, in this case, differed in several aspects from those of the first autopsy case of A/H1N1pdm09 infection-associated ARDS in Japan, reported during the 2009 pandemic season. In conclusion, pathological and molecular biological examinations suggested that in the post-pandemic season A/H1N1pdm09 infection, the infectionassociated ARDS was not caused by direct infection-induced damage to the alveolar epithelial cells but was rather a result of indirect sepsis-mediated endothelial cell damage. | |||||
書誌情報 |
Japanese Journal of Infectious Diseases 巻 70, 号 2, p. 197-200, 発行日 2017-03-24 |
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出版者 | ||||||
出版者 | 国立感染症研究所 | |||||
出版者別言語 | ||||||
National Institute of Infectious Diseases | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13446304 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18842836 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.7883/yoken.JJID.2016.120 | |||||
権利 | ||||||
権利情報 | c 2017 National Institute of Infectious Diseases | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Japanese Journal of Infectious Diseases, 70(2), pp.197-200; 2017 |