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WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3
http://hdl.handle.net/10069/37492
http://hdl.handle.net/10069/374928e9cfd5b-69f0-47ad-9042-b46216baed4c
名前 / ファイル | ライセンス | アクション |
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CanSci108_520.pdf (979.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-06-05 | |||||
タイトル | ||||||
タイトル | WP1066 suppresses macrophage cell death induced by inflammasome agonists independently of its inhibitory effect on STAT3 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Cell death | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | glioma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | macrophage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | NLRP3 inflammasome | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | STAT3 | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Honda, Shino
× Honda, Shino× Sadatomi, Daichi× Yamamura, Yasuo× Nakashioya, Kazutaka× Tanimura, Susumu× Takeda, Kohsuke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The compound WP1066 was originally synthesized by modifying the structure of AG490, which inhibits the activation of signal transducer and activator of transcription 3 (STAT3) by directly targeting Janus kinases (JAKs). WP1066 exhibits stronger anti-cancer activity than AG490 against malignant glioma and other cancer cells and is regarded as a promising therapeutic agent. By screening a small library of target-known compounds, we identified WP1066 as an inhibitor of macrophage cell death induced by agonists of the NLRP3 inflammasome, an intracellular protein complex required for the processing of the proinflammatory cytokine interleukin (IL)-1β. WP1066 strongly inhibited cell death as well as extracellular release of IL-1β induced by inflammasome agonists in mouse peritoneal exudate cells and human leukemia monocytic THP-1 cells that were differentiated into macrophagic cells by treatment with PMA. However, inflammasome agonists did not increase STAT3 phosphorylation, and another JAK inhibitor, ruxolitinib, did not inhibit cell death, although it strongly inhibited basal STAT3 phosphorylation. Thus, WP1066 appears to suppress macrophage cell death independently of its inhibitory effect on STAT3. In contrast, WP1066 itself induced the death of undifferentiated THP-1 cells, suggesting that WP1066 differentially modulates cell death in a context-dependent manner. Consistent with previous findings, WP1066 induced the death of human glioma A172 and T98G cells. However, neither ruxolitinib nor AG490, the former of which completely suppressed STAT3 phosphorylation, induced the death of these glioma cells. These results suggest that WP1066 targets cell death-modulating molecules other than those involved in JAK-STAT3 signaling. | |||||
書誌情報 |
Cancer Science 巻 108, 号 3, p. 520-527, 発行日 2017-03 |
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出版者 | ||||||
出版者 | 日本癌学会 | |||||
出版者別言語 | ||||||
Japanese Cancer Association | ||||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13479032 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1111/cas.13154 | |||||
権利 | ||||||
権利情報 | c 2017 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. | |||||
権利 | ||||||
権利情報 | This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Cancer Science, 108(3), pp.520-527; 2017 |