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Effects of Perfluoro Organic Compound Toxicity on Nematode Caenorhabditis elegans Fecundity
http://hdl.handle.net/10069/8371
http://hdl.handle.net/10069/83713b14b856-c462-48aa-83ba-5577db8a8c42
名前 / ファイル | ライセンス | アクション |
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JHS50_545.pdf (639.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-10-12 | |||||
タイトル | ||||||
タイトル | Effects of Perfluoro Organic Compound Toxicity on Nematode Caenorhabditis elegans Fecundity | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Caenorhabditis elegans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sublethal toxicity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bioassay | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | perfluoro organic compound | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tominaga, Nobuaki
× Tominaga, Nobuaki× Kohra, Shinya× Iguchi, Taisen× Arizono, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Toxicity studies using the nematode Caenorhabditis elegans (C. elegans) as a model organism have shown that perfluoro organic compounds have sub-lethal toxicity at the 10 pM-100 nM range on multi-generation assays. We examined the acute lethal toxicity and multi-generational sublethal toxicity (fecundity and reproduction) of perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA) and salts of perfluoro-1-octansulfonic acid (PFOS) using 1.7% agar Nematode Growth Medium (NGM) plates. The fluorine compounds affected the fecundity of C. elegans at concentrations 105- to 108-fold lower than the median effective concentrations (EC50). In particular, worm abundance during the first generation did not differ significantly from controls, while in contrast, the number of worms in the fourth generation at 10 pM PFOS-tetraethylammonium (TEA) decreased significantly to about 50% of control (p < 0.01) and the number of eggs and worms in the fourth generation at 1 nM PFNA decreased significantly to about 30% of control (p < 0.01). However, no dose-response relationship was observed in this study. We confirmed that perfluoro organic compounds strongly disrupt fecundity in C. elegans. | |||||
書誌情報 |
Journal of Health Science 巻 50, 号 5, p. 545-550, 発行日 2004-10 |
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出版者 | ||||||
出版者 | Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13449702 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5207 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11316464 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/jhs.50.545 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1248/jhs.50.545 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Health Science v.50(5) p.545-550, 2004 |