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Caenorhabditis elegans Responses to Specific Steroid Hormones
http://hdl.handle.net/10069/8373
http://hdl.handle.net/10069/837386dc8560-2d97-4b07-9c92-3f077096f29c
名前 / ファイル | ライセンス | アクション |
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JHS49_28.pdf (154.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-10-12 | |||||
タイトル | ||||||
タイトル | Caenorhabditis elegans Responses to Specific Steroid Hormones | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Caenorhabditis elegans | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | reproduction | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | fecundity | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | endocrine disrupting chemical | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | steroid hormone | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Tominaga, Nobuaki
× Tominaga, Nobuaki× Ura, Kazuhiro× Kawakami, Masato× Kawaguchi, Tomoaki× Kohra, Shinya× Mitsui, Yoshinori× Iguchi, Taisen× Arizono, Koji |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | In this paper, Caenorhabditis elegans (C. elegans) is proposed as a model organism for studying chemical effects over multiple generations. We investigated whether C. elegans responds to vertebrate steroid hormones. We found that estrogenic steroids, especially estradiol (E2), have a cholesterol-like potency in supporting the reproduction of C. elegans. In contrast, testosterone (TS) and diethylstilbestrol (DES) did not display this potency. On the other hand, E2, TS and DES supressed the fecundity rate of C. elegans, when culture carried out with cholesterol. Moreover effect of TS accumulated over generation, in contrast to the other chemicals tested. These data suggested that with convenient biomarkers such as fecundity, C. elegans might be an effective model organism for studying chemical actions, including the disruption of reproduction. | |||||
書誌情報 |
Journal of Health Science 巻 49, 号 1, p. 28-33, 発行日 2003-02 |
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出版者 | ||||||
出版者 | Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 13449702 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5207 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11316464 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/jhs.49.28 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1248/jhs.49.28 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Health Science v.49(1) p.28-33, 2003 |