WEKO3
アイテム
{"_buckets": {"deposit": "13383b92-2490-4995-8f9e-5862eea0359c"}, "_deposit": {"created_by": 2, "id": "23173", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "23173"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00023173", "sets": ["74"]}, "author_link": ["97855", "97852", "97853", "97856", "97854", "97857"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-04", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "4", "bibliographicPageEnd": "597", "bibliographicPageStart": "595", "bibliographicVolumeNumber": "27", "bibliographic_titles": [{"bibliographic_title": "Biological \u0026 Pharmaceutical Bulletin"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Animal models prepared by treatment with carbon tetrachloride (CCl4) have been used to examine drug disposition in hepatic disorder. However, previous studies demonstrated that systemic administration of CCl4 impaired not only hepatic but also renal function. We recently reported that application of CCl4 to the rat liver surface produced hepatic damage without impairing renal function. In the present study, we examined the pharmacokinetics of phenol red in our developed rat model. The rats treated with CCl4 by liver surface application exhibited decreases in the biliary clearance of phenol red in comparison with normal rats from 0.54±0.03 to 0.31±0.06 ml/min, suggesting hepatic damage. In these rats, the renal clearance of phenol red did not decrease (0.50±0.16 ml/min vs. 0.46±0.07 ml/min in normal rats). On the other hand, oral and intraperitoneal treatments with CCl4 reduced not only the biliary clearance of phenol red (0.34±0.03 ml/min in p.o. treated rats, 0.18±0.01 ml/min in i.p. treated rats) but also the renal clearance (0.26±0.05 ml/min in p.o. treated rats, 0.18±0.06 ml/min in i.p. treated rats) as compared with normal rats. These findings indicate that the rat model of liver damage prepared by liver surface application of CCl4 is useful to investigate the effects of hepatic disorder on the pharmacokinetics of drugs.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Biological \u0026 Pharmaceutical Bulletin v.27(4) p.595-597, 2004", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Pharmaceutical Society of Japan"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "15056875", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1248/bpb.27.595", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_42": {"attribute_name": "関係URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://dx.doi.org/10.1248/bpb.27.595"}]}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10885497", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09186158", "subitem_source_identifier_type": "ISSN"}]}, "item_2_source_id_8": {"attribute_name": "EISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1347-5215", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Mukai, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "97852", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mera, Kunihiro"}], "nameIdentifiers": [{"nameIdentifier": "97853", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nishida, Koyo"}], "nameIdentifiers": [{"nameIdentifier": "97854", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakashima, Mikiro"}], "nameIdentifiers": [{"nameIdentifier": "97855", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "97856", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Junzo"}], "nameIdentifiers": [{"nameIdentifier": "97857", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "BPBul27_595.pdf", "filesize": [{"value": "66.5 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 66500.0, "url": {"label": "BPBul27_595.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/23173/files/BPBul27_595.pdf"}, "version_id": "e06e6467-3a98-4ffd-b845-335e9be46ed2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "animal model", "subitem_subject_scheme": "Other"}, {"subitem_subject": "liver damage", "subitem_subject_scheme": "Other"}, {"subitem_subject": "carbon tetrachloride", "subitem_subject_scheme": "Other"}, {"subitem_subject": "liver targeting", "subitem_subject_scheme": "Other"}, {"subitem_subject": "phenol red", "subitem_subject_scheme": "Other"}, {"subitem_subject": "pharmacokinetics", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Pharmacokinetics of Phenol Red in Rat Models of Liver Damage Prepared by Liver Targeting of Carbon Tetrachloride", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Pharmacokinetics of Phenol Red in Rat Models of Liver Damage Prepared by Liver Targeting of Carbon Tetrachloride"}]}, "item_type_id": "2", "owner": "2", "path": ["74"], "permalink_uri": "http://hdl.handle.net/10069/8388", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-10-12"}, "publish_date": "2007-10-12", "publish_status": "0", "recid": "23173", "relation": {}, "relation_version_is_last": true, "title": ["Pharmacokinetics of Phenol Red in Rat Models of Liver Damage Prepared by Liver Targeting of Carbon Tetrachloride"], "weko_shared_id": -1}
Pharmacokinetics of Phenol Red in Rat Models of Liver Damage Prepared by Liver Targeting of Carbon Tetrachloride
http://hdl.handle.net/10069/8388
http://hdl.handle.net/10069/8388aba44d77-3c1d-450e-a793-36ba7434323b
名前 / ファイル | ライセンス | アクション |
---|---|---|
BPBul27_595.pdf (66.5 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-10-12 | |||||
タイトル | ||||||
タイトル | Pharmacokinetics of Phenol Red in Rat Models of Liver Damage Prepared by Liver Targeting of Carbon Tetrachloride | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | animal model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver damage | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | carbon tetrachloride | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver targeting | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | phenol red | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacokinetics | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mukai, Takahiro
× Mukai, Takahiro× Mera, Kunihiro× Nishida, Koyo× Nakashima, Mikiro× Sasaki, Hitoshi× Nakamura, Junzo |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Animal models prepared by treatment with carbon tetrachloride (CCl4) have been used to examine drug disposition in hepatic disorder. However, previous studies demonstrated that systemic administration of CCl4 impaired not only hepatic but also renal function. We recently reported that application of CCl4 to the rat liver surface produced hepatic damage without impairing renal function. In the present study, we examined the pharmacokinetics of phenol red in our developed rat model. The rats treated with CCl4 by liver surface application exhibited decreases in the biliary clearance of phenol red in comparison with normal rats from 0.54±0.03 to 0.31±0.06 ml/min, suggesting hepatic damage. In these rats, the renal clearance of phenol red did not decrease (0.50±0.16 ml/min vs. 0.46±0.07 ml/min in normal rats). On the other hand, oral and intraperitoneal treatments with CCl4 reduced not only the biliary clearance of phenol red (0.34±0.03 ml/min in p.o. treated rats, 0.18±0.01 ml/min in i.p. treated rats) but also the renal clearance (0.26±0.05 ml/min in p.o. treated rats, 0.18±0.06 ml/min in i.p. treated rats) as compared with normal rats. These findings indicate that the rat model of liver damage prepared by liver surface application of CCl4 is useful to investigate the effects of hepatic disorder on the pharmacokinetics of drugs. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 27, 号 4, p. 595-597, 発行日 2004-04 |
|||||
出版者 | ||||||
出版者 | Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 15056875 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.27.595 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1248/bpb.27.595 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin v.27(4) p.595-597, 2004 |