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Surface Plasmon Resonance Analysis for the Screening of Anti-prion Compounds
http://hdl.handle.net/10069/8397
http://hdl.handle.net/10069/839755e90575-ae54-4e49-8776-3a06f2f2cb31
名前 / ファイル | ライセンス | アクション |
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BPBul29_927.pdf (332.4 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-10-12 | |||||
タイトル | ||||||
タイトル | Surface Plasmon Resonance Analysis for the Screening of Anti-prion Compounds | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | anti-prion compound | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | surface plasmon resonance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | scrapie-infected cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | screening | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | recombinant prion protein | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kawatake, Satoshi
× Kawatake, Satoshi× Nishimura, Yuki× Sakaguchi, Suehiro× Iwaki, Toru× Doh-Ura, Katsumi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The interaction of anti-prion compounds and amyloid binding dyes with a carboxy-terminal domain of prion protein (PrP121?231) was examined using surface plasmon resonance (SPR) and compared with inhibition activities of abnormal PrP formation in scrapie-infected cells. Most examined compounds had affinities for PrP121?231: antimalarials had low affinities, whereas Congo red, phthalocyanine and thioflavin S had high affinities. The SPR binding response correlated with the inhibition activity of abnormal PrP formation. Several drugs were screened using SPR to verify the findings: propranolol was identified as a new anti-prion compound. This fact indicates that drug screenings by this assay are useful. | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 29, 号 5, p. 927-932, 発行日 2006-05 |
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出版者 | ||||||
出版者 | Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5215 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 16651721 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/bpb.29.927 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1248/bpb.29.927 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin v.29(5) p.927-932, 2006 |