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Regulation of Lithospermic Acid B and Shikonin Production in Lithospermum erythrorhizon Cell Suspension Cultures
http://hdl.handle.net/10069/8405
http://hdl.handle.net/10069/840556b1b16d-e197-4ece-a652-bb7a43e98ee0
名前 / ファイル | ライセンス | アクション |
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CPBul50_1086.pdf (78.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-10-12 | |||||
タイトル | ||||||
タイトル | Regulation of Lithospermic Acid B and Shikonin Production in Lithospermum erythrorhizon Cell Suspension Cultures | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Lithospermum erythrorhizon | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | plant cell culture | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | lithospermic acid B | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | shikonin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | light | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | nitrogen source | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Yamamoto, Hirobumi
× Yamamoto, Hirobumi× Zhao, Ping× Yazaki, Kazufumi× Inoue, Kenichiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Cell suspension cultures of Lithospermum erythrorhizon produced a large amount of lithospermic acid B, a caffeic acid tetramer, as well as shikonin derivatives (each ca. 10% of dry wt.) when cultured in shikonin production medium M-9. Various culture factors for increasing the production of lithospermic acid B were investigated. Lithospermic acid B production was inhibited by 2, 4-D or NH4+, whereas it was stimulated by Cu2+. These regulatory patterns were similar to those for the production of shikonin derivatives in these cell cultures, suggestive of close relations and similar metabolic regulation between the production of these compounds. Cultivation under light illumination, however, showed that these metabolisms were independently regulated. In particular, blue light showed a stimulatory effect on lithospermic acid B production, while shikonin production was strongly inhibited, indicative of an effective condition for lithospermic acid B production. | |||||
書誌情報 |
Chemical & Pharmaceutical Bulletin 巻 50, 号 8, p. 1086-1090, 発行日 2002-08 |
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出版者 | ||||||
出版者 | Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00092363 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1347-5223 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00602100 | |||||
PubMed番号 | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | PMID | |||||
関連識別子 | 12192141 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1248/cpb.50.1086 | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1248/cpb.50.1086 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Chemical & Pharmaceutical Bulletin v.50(8) p.1086-1090, 2002 |