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Absorption characteristics of dextrans with different molecular weights from the liver surface membrane in rats: implications for targeting to the liver
http://hdl.handle.net/10069/6487
http://hdl.handle.net/10069/6487bcfb1394-0f4a-4167-b616-6f368334c8c0
名前 / ファイル | ライセンス | アクション |
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JDT4_141.pdf (83.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-02-14 | |||||
タイトル | ||||||
タイトル | Absorption characteristics of dextrans with different molecular weights from the liver surface membrane in rats: implications for targeting to the liver | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Sato, Norihito× Sasaki, Hitoshi× Nakamura, Junzo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | We examined the importance of molecular weight on the absorption from the liver surface in rats using fluorescein isothiocyanate-dextrans (FDs) with molecular weights of 4,400 (FD-4), 9,300 (FD-10), 40,500 (FD-40) or 69,000 (FD-70). After application of FDs (5 mg) to the rat liver surface employing a cylindrical glass cell (i.d. 9 mm), each FD appeared gradually in the plasma, and the in vivo behavior was explained by two-compartment model with first-order absorption. The absorption ratios of FDs from the rat liver surface at 6 h, calculated from the amount recovered from the glass cell, decreased with an increase in the molecular weight (44.5% for FD-4, 29.3% for FD-10, 5.1% for FD-40 and 2.2% for FD-70). A linear relationship was observed between the absorption rate constant and the reciprocal value with square root of molecular weight of the model compounds. The limit of absorption from the rat liver surface was extrapolated to be at a molecular weight of 70,000. Furthermore, absorbed FDs were accumulated in the liver, as high liver/plasma concentration ratio as compared with that of i.v. administration. We clarified the molecular weight dependence of drug absorption from the liver surface in rats. Moreover, the liver surface application appeared to be a promising route with enhancing the efficacy of drug targeting to the liver. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | without figures | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | グラフなし | |||||
書誌情報 |
Journal of Drug Targeting 巻 4, 号 3, p. 141-150, 発行日 1996 |
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出版者 | ||||||
出版者 | Taylor & Francis | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1061186X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11004960 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 8959486 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/10611869609015971 | |||||
権利 | ||||||
権利情報 | This is an electronic version of an article published in Journal of Drug Targeting, 4 (3), 141-150, 1996. the Journal of Drug Targeting is available online at: http://www.informaworld.com/openurl?genre=article&issn=1061-186X&volume=4&issue=3&spage=141. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Drug Targeting, 4 (3), 141-150, 1996 |