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Delivery advantage to the unilateral kidney by direct drug application to the kidney surface in rats and pharmacokinetic verification based on a physiological model
http://hdl.handle.net/10069/6488
http://hdl.handle.net/10069/64882a8c9d7c-341f-4f8c-920b-1d453e259164
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JDT13_215_fig2-6.pdf (33.3 kB)
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JDT13_215_fig1.pdf (12.1 kB)
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JDT13_215.pdf (85.2 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-02-14 | |||||
タイトル | ||||||
タイトル | Delivery advantage to the unilateral kidney by direct drug application to the kidney surface in rats and pharmacokinetic verification based on a physiological model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Kidney surface | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | targeting | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | unilateral delivery | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | physiological model | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | pharmacokinetics | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Kamenosono, Manabu× Kuma, Akiko× Fumoto, Shintaro× Mukai, Takahiro× Nakashima, Mikiro× Sasaki, Hitoshi× Nakamura, Junzo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The objective of this study was to evaluate the drug delivery advantage to the unilateral kidney by direct drug application to the rat kidney surface based on a physiological pharmacokinetic model. Under anesthesia, a cylindrical diffusion cell (i.d. 6 mm, area 0.28 cm(2)) was attached to the right kidney surface in rats. Phenolsulfonphthalein (PSP), an organic anion chosen as a model compound, was added into the diffusion cell. The free PSP concentration in the right (applied) kidney after application to the right kidney surface at a dose of 1 mg was significantly higher than that of the left (non-applied) kidney until 60 min after application. Similarly, the urinary excretion rate of free PSP from the applied kidney was much faster than that from the non-applied kidney, with a 2.6 times larger excreted amount in 240 min. These results imply the possibility that a considerable drug delivery advantage to the unilateral kidney could be obtained after direct absorption from the kidney surface. This tendency was also observed at the other application doses of 0.3 and 1.5 mg. On the other hand, fluorescein isothiocyanate dextran (Mw 4400, FD-4) was equally excreted into the urine from each kidney and the renal concentrations in the applied and non-applied kidneys were almost the same, possibly due to the involvement of passive transport for the absorbed FD-4, i.e. glomerular filtration. The computer simulations of free PSP concentrations in the plasma and each kidney based on a physiological model after kidney surface application were consistent with the respective experimental data. Moreover, the delivery advantage of kidney surface application of PSP was verified by its comparison with other routes such as i.v. and i.a. administrations. | |||||
書誌情報 |
Journal of Drug Targeting 巻 13, 号 4, p. 215-223, 発行日 2005-05 |
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出版者 | ||||||
出版者 | Taylor & Francis | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1061186X | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA11004960 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 16051533 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1080/10611860500159097 | |||||
権利 | ||||||
権利情報 | This is an electronic version of an article published in J Drug Target. 2005 May13(4):215-23. the Journal of Drug Targeting is available online at: http://taylorandfrancis.metapress.com/openurl.asp?genre=article&id=doi:10.1080/10611860500159097. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1080/10611860500159097 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Drug Targeting, 13 (4), 215-223, 2005 |