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Absorption characteristics of model compounds with different molecular weights from the serosal caecal surface in rats
http://hdl.handle.net/10069/6676
http://hdl.handle.net/10069/6676972495bc-0743-4103-ab0a-f540782236ec
名前 / ファイル | ライセンス | アクション |
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JPP54_1005.pdf (153.7 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-02-21 | |||||
タイトル | ||||||
タイトル | Absorption characteristics of model compounds with different molecular weights from the serosal caecal surface in rats | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Nose, Seiichi× Kuma, Akiko× Mukai, Takahiro× Kawakami, Shigeru× Nakashima, Mikiro× Sasaki, Hitoshi× Toshiyuki, Sakaeda× Nakamura, Junzo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study is to clarify the absorption characteristics of drugs across the serosal cecal surface membrane occupying a large absorption area in the peritoneal cavity in rats. Absorptions of phenolsulphonphthalein (PSP) and fluorescein isothiocyanate-dextrans (FDs) as model drugs after application to the rat serosal cecal surface were investigated in rats, employing a cylindrical diffusion cell. PSP was absorbed from the rat serosal cecal surface, followed by appearance in the plasma and bile. The time course of the remaining PSP amount in the diffusion cell obeyed first-order kinetics, and its rate constant Ka was calculated to be 8.01 x 10-3 min-1. No significant difference was seen in the absorption ratio of PSP which was approximately 90 % in 6 h among three doses (0.3, 0.5 and 1 mg), suggesting a linearity of absorption. Moreover, the absorption ratios of FDs from the rat serosal cecal surface at 3 h decreased with an increase in the molecular weight (24.7% for FD-4, 12.8% for FD-10 and 3.4% for FD-40). | |||||
書誌情報 |
Journal of Pharmacy and Pharmacology 巻 54, 号 7, p. 1005-1009, 発行日 2002-07 |
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出版者 | ||||||
出版者 | Pharmaceutical Press | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 00223573 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA00704643 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 12162704 | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Pharmacy and Pharmacology, 54 (7), 1005-1009, 2002 |