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Effect of albumin on the absorption of phenol red, bromphenol blue and bromosulphonphthalein as model drugs from the liver surface membrane in rats,
http://hdl.handle.net/10069/6679
http://hdl.handle.net/10069/6679a76305a0-9940-4c10-bbde-1a549f72a667
名前 / ファイル | ライセンス | アクション |
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BPBul18_1548.pdf (97.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-02-22 | |||||
タイトル | ||||||
タイトル | Effect of albumin on the absorption of phenol red, bromphenol blue and bromosulphonphthalein as model drugs from the liver surface membrane in rats, | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | protein binding | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | absorption | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | liver surface | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | organic anion | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | bovine serum albumin | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Sato, Norihito× Sasaki, Hitoshi× Nakamura, Junzo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The effect of bovine serum albumin (BSA) on drug absorption from the liver surface in rats was examined by using three organic anions (phenol red, bromphenol blue and bromosulphonphthalein) as model drugs which have a high affinity for albumin. The binding ratio of the model drugs (3 mg/ml in phosphate buffer) to BSA varied widely at a BSA concentration of 0.1--10% (w/v). The model drugs (3 mg/ml x 0.1 ml) with or without BSA were applied to the rat liver surface in vivo employing a cylindrical glass cell (i.d. 9 mm, area 0.64 cm2). The absorption ratios of the model drugs from the rat liver surface at 6h, calculated from the amount recovered from the glass cell, decreased with an increase in BSA concentration. A similar trend was observed with biliary recovery of the model drugs. A marked reduction in the absorption ratio was seen with bromosulphonphthalein, which has the highest binding activity to BSA among the three organic anions. Accordingly, protein binding appears to be a significant factor with respect to the drug absorption from the liver surface. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | グラフなし | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | without graphs | |||||
書誌情報 |
Biological & Pharmaceutical Bulletin 巻 18, 号 11, p. 1548-1550, 発行日 1995-11 |
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出版者 | ||||||
出版者 | 日本薬学会 | |||||
出版者 | ||||||
出版者 | The Pharmaceutical Society of Japan | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09186158 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10885497 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 8593477 | |||||
権利 | ||||||
権利情報 | Copyright (c) 1995 The Pharmaceutical Society of Japan | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Biological & Pharmaceutical Bulletin, 18 (11), p.1548-1550, 1995 |