WEKO3
アイテム
{"_buckets": {"deposit": "4c872511-4fb3-4062-9ad2-f3dabcc8819f"}, "_deposit": {"created_by": 2, "id": "24198", "owners": [2], "pid": {"revision_id": 0, "type": "depid", "value": "24198"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00024198", "sets": ["74"]}, "author_link": ["101535", "101536", "101534", "101537", "101538", "101533"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2004-11", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "3", "bibliographicPageEnd": "711", "bibliographicPageStart": "705", "bibliographicVolumeNumber": "58", "bibliographic_titles": [{"bibliographic_title": "European Journal of Pharmaceutics and Biopharmaceutics"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "The aim of the present study is to clarify the absorption mechanism of a drug from the kidney surface membrane in rats. We studied the absorption characteristics of phenolsulfonphthalein (PSP) and other compounds with different molecular weights after their application to the rat kidney surface in vivo, employing a cylindrical diffusion cell (i.d. 6 mm, area 0.28 cm2). The time course of free PSP amounts remaining in the diffusion cell obeyed first-order kinetics at a dose of 1 mg, and its rate constant ka was calculated to be 0.0137 min?1. Absorption ratios of PSP in 4 h were calculated (from the amount recovered from the diffusion cell) to be 91.4, 96.4 and 97.7% at doses of 0.5, 1 and 1.5 mg, respectively. The area under the curve for the plasma concentration profile of free PSP was proportional to the application dose. It is thus suggested that the absorption process of PSP from the rat kidney surface does not approach saturation at a dose of 1.5 mg. Also, no significant difference was seen in the ka values within the dose range of 0.5?1.5 mg, which were estimated by curve-fitting the plasma concentration profiles of free PSP in a two-compartment model with first-order absorption. Furthermore, we examined the importance of molecular weight on the absorption from the kidney surface using fluorescein isothiocyanate-dextrans (FDs) with molecular weights of 4400 (FD-4), 11,000 (FD-10), 40,500 (FD-40) or 69,000 (FD-70), including the organic anions bromphenol blue and bromosulfonphthalein. The absorption ratios of FDs from the rat kidney surface in 6 h decreased with an increase in the molecular weight (76.1% for FD-4, 54.4% for FD-10, 11.5% for FD-40 and 3.9% for FD-70). A linear relationship was observed between ka and the reciprocal value of z the square root of the molecular weight of these compounds. The limit of absorption from the rat kidney surface was extrapolated to be at a molecular weight of approximately 130,000.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "European Journal of Pharmaceutics and Biopharmaceutics, 58 (3), 705-711, 2004", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier"}]}, "item_2_relation_11": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "15451548", "subitem_relation_type_select": "PMID"}}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.ejpb.2004.04.016", "subitem_relation_type_select": "DOI"}}]}, "item_2_relation_42": {"attribute_name": "関係URI", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://dx.doi.org/10.1016/j.ejpb.2004.04.016"}]}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "Copyright c 2004 Elsevier B.V. All rights reserved."}]}, "item_2_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AA10836618", "subitem_source_identifier_type": "NCID"}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "09396411", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Nishida, Koyo"}], "nameIdentifiers": [{"nameIdentifier": "101533", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomiyama, Naoki"}], "nameIdentifiers": [{"nameIdentifier": "101534", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mukai, Takahiro"}], "nameIdentifiers": [{"nameIdentifier": "101535", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakashima, Mikiro"}], "nameIdentifiers": [{"nameIdentifier": "101536", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sasaki, Hitoshi"}], "nameIdentifiers": [{"nameIdentifier": "101537", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakamura, Junzo"}], "nameIdentifiers": [{"nameIdentifier": "101538", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "EPB58_705_fig.pdf", "filesize": [{"value": "30.4 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 30400.0, "url": {"label": "EPB58_705_fig.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/24198/files/EPB58_705_fig.pdf"}, "version_id": "7cfc445d-5a1a-41de-9f89-cfb042dece5d"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "EPB58_705.pdf", "filesize": [{"value": "83.2 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 83200.0, "url": {"label": "EPB58_705.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/24198/files/EPB58_705.pdf"}, "version_id": "17cc3111-2470-4e8b-822c-d1f86f48da26"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Absorption", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Kidney surface", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Rat", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Molecular weight", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Pharmacokinetics", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Targeting", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Absorption characteristics of compounds with different molecular weights after application to the unilateral kidney surface in rats", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Absorption characteristics of compounds with different molecular weights after application to the unilateral kidney surface in rats"}]}, "item_type_id": "2", "owner": "2", "path": ["74"], "permalink_uri": "http://hdl.handle.net/10069/6483", "pubdate": {"attribute_name": "公開日", "attribute_value": "2007-02-14"}, "publish_date": "2007-02-14", "publish_status": "0", "recid": "24198", "relation": {}, "relation_version_is_last": true, "title": ["Absorption characteristics of compounds with different molecular weights after application to the unilateral kidney surface in rats"], "weko_shared_id": -1}
Absorption characteristics of compounds with different molecular weights after application to the unilateral kidney surface in rats
http://hdl.handle.net/10069/6483
http://hdl.handle.net/10069/64830bb574e4-6682-470c-90a7-4c5c95ff30a9
名前 / ファイル | ライセンス | アクション |
---|---|---|
EPB58_705_fig.pdf (30.4 kB)
|
|
|
EPB58_705.pdf (83.2 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2007-02-14 | |||||
タイトル | ||||||
タイトル | Absorption characteristics of compounds with different molecular weights after application to the unilateral kidney surface in rats | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Absorption | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Kidney surface | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Rat | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Molecular weight | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pharmacokinetics | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Targeting | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Tomiyama, Naoki× Mukai, Takahiro× Nakashima, Mikiro× Sasaki, Hitoshi× Nakamura, Junzo |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The aim of the present study is to clarify the absorption mechanism of a drug from the kidney surface membrane in rats. We studied the absorption characteristics of phenolsulfonphthalein (PSP) and other compounds with different molecular weights after their application to the rat kidney surface in vivo, employing a cylindrical diffusion cell (i.d. 6 mm, area 0.28 cm2). The time course of free PSP amounts remaining in the diffusion cell obeyed first-order kinetics at a dose of 1 mg, and its rate constant ka was calculated to be 0.0137 min?1. Absorption ratios of PSP in 4 h were calculated (from the amount recovered from the diffusion cell) to be 91.4, 96.4 and 97.7% at doses of 0.5, 1 and 1.5 mg, respectively. The area under the curve for the plasma concentration profile of free PSP was proportional to the application dose. It is thus suggested that the absorption process of PSP from the rat kidney surface does not approach saturation at a dose of 1.5 mg. Also, no significant difference was seen in the ka values within the dose range of 0.5?1.5 mg, which were estimated by curve-fitting the plasma concentration profiles of free PSP in a two-compartment model with first-order absorption. Furthermore, we examined the importance of molecular weight on the absorption from the kidney surface using fluorescein isothiocyanate-dextrans (FDs) with molecular weights of 4400 (FD-4), 11,000 (FD-10), 40,500 (FD-40) or 69,000 (FD-70), including the organic anions bromphenol blue and bromosulfonphthalein. The absorption ratios of FDs from the rat kidney surface in 6 h decreased with an increase in the molecular weight (76.1% for FD-4, 54.4% for FD-10, 11.5% for FD-40 and 3.9% for FD-70). A linear relationship was observed between ka and the reciprocal value of z the square root of the molecular weight of these compounds. The limit of absorption from the rat kidney surface was extrapolated to be at a molecular weight of approximately 130,000. | |||||
書誌情報 |
European Journal of Pharmaceutics and Biopharmaceutics 巻 58, 号 3, p. 705-711, 発行日 2004-11 |
|||||
出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09396411 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10836618 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | PMID | |||||
関連識別子 | 15451548 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.ejpb.2004.04.016 | |||||
権利 | ||||||
権利情報 | Copyright c 2004 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1016/j.ejpb.2004.04.016 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European Journal of Pharmaceutics and Biopharmaceutics, 58 (3), 705-711, 2004 |