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Effect of viscous additives on drug absorption from the liver surface in rats using phenol red as a model
http://hdl.handle.net/10069/6484
http://hdl.handle.net/10069/64840ed38c29-6835-4834-8717-87bae97b9c63
名前 / ファイル | ライセンス | アクション |
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EPB50_397.pdf (122.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2007-02-14 | |||||
タイトル | ||||||
タイトル | Effect of viscous additives on drug absorption from the liver surface in rats using phenol red as a model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Viscous additive | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Absorption | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Liver surface | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Phenol rednext term | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pharmacokinetic analysis | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Nishida, Koyo
× Nishida, Koyo× Nakakoga, Yuki× Sato, Norihito× Kawakami, Shigeru× Mukai, Takahiro× Sasaki, Hitoshi× Sakaeda, Toshiyuki× Nakamura, Junzo |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The purpose of this study is to obtain information that can be used to improve controlled release and residence time of drugs on the liver surface. Using carboxymethylcellulose sodium salt (CMC-Na) and polyvinyl alcohol (PVA), we examined the effect of viscous formulations on the absorption of phenol red as a model. In the presence of 3% CMC-Na or 15% PVA, the maximum plasma concentration of phenol red decreased after application to the rat liver surface using a cylindrical glass cell. The absorption ratios in 6 h calculated from the remaining amount of phenol red in the glass cell were 68.6, 60.5 and 48.7% (control: 73.1%) in the presence of 1 or 3% CMC-Na and 15% PVA, respectively. As a result of the reduction in the absorption ratio, the amount of phenol red excreted into the bile and urine in 6 h was decreased by the addition of the viscous additives. The decrease in absorption rate was characterized by a pharmacokinetic analysis of the plasma concentration profile. The change in absorption rate differed between the viscous additives, reflecting the result of the in vitro release experiment. Accordingly, the possibility that the drug absorption rate from the liver surface can be altered by viscous additives was suggested to have a promising prospect for therapeutic use. | |||||
書誌情報 |
European Journal of Pharmaceutics and Biopharmaceutics 巻 50, 号 3, p. 397-402, 発行日 2000-11 |
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出版者 | ||||||
出版者 | Elsevier | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09396411 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AA10836618 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/S0939-6411(00)00112-0 | |||||
権利 | ||||||
権利情報 | Copyright c 2004 Elsevier B.V. All rights reserved. | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
関係URI | ||||||
関連名称 | http://dx.doi.org/10.1016/S0939-6411(00)00112-0 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | European Journal of Pharmaceutics and Biopharmaceutics, 50 (3), 397-402, 2000 |