WEKO3
アイテム
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E染色,志方によるオルセイン染色を行い,肝組織型,組織HBs-Agの有無,間質炎症反応の有無, Dysplasiaの有無,肝細胞癌のGrade,及びこれらの相互の関係について検討した.肝組織HBs-Agは,萎縮性肝硬変+肝細胞癌の群では高率で60.6%に陽性であった. 196例の肝細胞癌のうち,非癌部の組織が萎縮性肝硬変でないものは41例でこのうちの14例にHBs-Agが認められた.この14例のうち6例は非癌部の組織が軽度の線維かのみか,又は特に著変を認めないものであり, HBs-Agは直接にoncogenic作用を持つという仮説を支技する所見と思われた.萎縮性肝硬変症例についてLiver cell dysplasiaの有無について検討したが,肝細胞癌の合併の有無により,陽性率に差がみられた.さらに,長与B型の萎縮性肝硬変群では, HBs-Agの陽性率とDysplasiaの出現との間に有意な関係がみられた.", "subitem_description_type": "Abstract"}, {"subitem_description": "A total of 953 cases of various types of liver diseases were selected for examination from 6339 autopsies performed in Nagasaki University Hospital from 1964 through 1980. The association between HBs-Ag in liver tissue and the histology of the liver was studied using Shikata\u0027s orcein staining method. Of the 6339 autopsies performed, 488 cases of atrophic liver cirrhosis (7.7%) and 303 cases of primary hepatocellular carcinoma (4.8%) were identified. These incidences of liver diseases were statistically significantly higher compared with those of national averages of Japan (5.2% and 3.5% respectively). A histological analysis of 953 cases indicated that 242 out of 488 cases of atrophic liver cirrhosis were associated with hepatocellular carcinoma (49.6%) and that 242 out of 303 cases of hepatocellular carcinoma were combined with atrophic liver cirrhosis (78.9%). No HBs-Ag was detected in the tissues of cases of acute liver atrophy or liver cirrhosis with the exception of atrophic liver cirrhosis. HBs-Ag was present in 6 out of 22 cases of subacute hepatitis (27.2%) and in 6 out of 37 chronic hepatitis (16.2%). The highest rate of detectable HBs-Ag was observed in the liver tissues of the subgroup of atrophic liver cirrhosis with hepatocellular carcinoma (60.6%). Among 196 cases of hepatocellular carcinoma examined, HBs-Ag was detected in 14 of those cases which did not exhibit atrophic liver cirrhosis. These results suggest that nepatocellular carcinoma can arise without setting of hepatitis B chronic liver cirrhosis and support the hypothesis that HBs-Ag may be directly oncogenic. Liver cell dysplasia was found in 69 out of 154 cases of atrophic liver cirrhosis with hepatocellular carcinoma (44.8%) and in 22 out of 122 cases of atrophic liver cirrhosis without hapatocellular carcinoma (18.0%). Furthermore, there was a strong correlation between the presence of HBs-Ag in the liver tissue of Nagayo\u0027s type B atrophic liver cirrhosis and the existence of cellular dysplasia.", "subitem_description_type": "Abstract"}]}, "item_3_description_64": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "熱帯医学 Tropical medicine 26(3). p123-136, 1984", "subitem_description_type": "Other"}]}, "item_3_full_name_3": {"attribute_name": "著者別名", "attribute_value_mlt": [{"nameIdentifiers": [{"nameIdentifier": "105791", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Toda, Yumiko"}]}, {"nameIdentifiers": [{"nameIdentifier": "105792", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Senba, Masachika"}]}, {"nameIdentifiers": [{"nameIdentifier": "105793", "nameIdentifierScheme": "WEKO"}], "names": [{"name": "Itakura, Hideyo"}]}]}, "item_3_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "長崎大学熱帯医学研究所"}]}, "item_3_source_id_10": {"attribute_name": "書誌レコードID", "attribute_value_mlt": [{"subitem_source_identifier": "AN00199644", "subitem_source_identifier_type": "NCID"}]}, "item_3_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "03855643", "subitem_source_identifier_type": "ISSN"}]}, "item_3_text_62": {"attribute_name": "sortkey", "attribute_value_mlt": [{"subitem_text_value": "P00123-P00136"}]}, "item_3_text_63": {"attribute_name": "出版者別言語", "attribute_value_mlt": [{"subitem_text_value": "Institute of Tropical Medicine, Nagasaki University"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "戸田, ゆみ子"}], "nameIdentifiers": [{"nameIdentifier": "105788", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "千馬, 正敬"}], "nameIdentifiers": [{"nameIdentifier": "105789", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "板倉, 英世"}], "nameIdentifiers": [{"nameIdentifier": "105790", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-12-24"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "tm26_03_04_t.pdf", "filesize": [{"value": "2.4 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2400000.0, "url": {"label": "tm26_03_04_t.pdf", "url": "https://nagasaki-u.repo.nii.ac.jp/record/25014/files/tm26_03_04_t.pdf"}, "version_id": "eb3aea8c-55c9-4d15-9e65-e8d262877c35"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "departmental bulletin paper", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "肝細胞癌発生におけるB型肝炎ウイルスの役割に関する病理組織学的研究", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "肝細胞癌発生におけるB型肝炎ウイルスの役割に関する病理組織学的研究"}]}, "item_type_id": "3", "owner": "2", "path": ["1845"], "permalink_uri": "http://hdl.handle.net/10069/4387", "pubdate": {"attribute_name": "公開日", "attribute_value": "2006-04-26"}, "publish_date": "2006-04-26", "publish_status": "0", "recid": "25014", "relation": {}, "relation_version_is_last": true, "title": ["肝細胞癌発生におけるB型肝炎ウイルスの役割に関する病理組織学的研究"], "weko_shared_id": -1}
肝細胞癌発生におけるB型肝炎ウイルスの役割に関する病理組織学的研究
http://hdl.handle.net/10069/4387
http://hdl.handle.net/10069/43874bb475af-46d0-4cbc-8f27-520d1d515385
名前 / ファイル | ライセンス | アクション |
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tm26_03_04_t.pdf (2.4 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | 肝細胞癌発生におけるB型肝炎ウイルスの役割に関する病理組織学的研究 | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
戸田, ゆみ子
× 戸田, ゆみ子× 千馬, 正敬× 板倉, 英世 |
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著者別名 | ||||||
姓名 | Toda, Yumiko | |||||
著者別名 | ||||||
姓名 | Senba, Masachika | |||||
著者別名 | ||||||
姓名 | Itakura, Hideyo | |||||
その他のタイトル | ||||||
その他のタイトル | Further Histological Study of the Role of Hepatitis B Infection on the Development of Hepatocellular Carcinoma | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | 1964年から1980年における長崎大学での剖検例6339例のうち,肝疾患を主病変とする症例953例について,検討した.全剖検例に占める肝疾患の比率は,萎縮性肝硬変(7.7%),肝細胞癌(4.8%)で,同期間における全日本の平均(日本剖検輯報による)の5.2%及び3.5%と比較し高率であり,統計学的に有意差を示した.又,488例の萎縮性肝硬変のうち242例(49.6%)に,肝細胞癌の合併がみられ,一方303例の肝細胞癌のうち242例(78.9%)に萎縮性肝硬変が認められた.上記953例のうち,組織学的に詳細な検討が可能であった652例につき, H. E染色,志方によるオルセイン染色を行い,肝組織型,組織HBs-Agの有無,間質炎症反応の有無, Dysplasiaの有無,肝細胞癌のGrade,及びこれらの相互の関係について検討した.肝組織HBs-Agは,萎縮性肝硬変+肝細胞癌の群では高率で60.6%に陽性であった. 196例の肝細胞癌のうち,非癌部の組織が萎縮性肝硬変でないものは41例でこのうちの14例にHBs-Agが認められた.この14例のうち6例は非癌部の組織が軽度の線維かのみか,又は特に著変を認めないものであり, HBs-Agは直接にoncogenic作用を持つという仮説を支技する所見と思われた.萎縮性肝硬変症例についてLiver cell dysplasiaの有無について検討したが,肝細胞癌の合併の有無により,陽性率に差がみられた.さらに,長与B型の萎縮性肝硬変群では, HBs-Agの陽性率とDysplasiaの出現との間に有意な関係がみられた. | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A total of 953 cases of various types of liver diseases were selected for examination from 6339 autopsies performed in Nagasaki University Hospital from 1964 through 1980. The association between HBs-Ag in liver tissue and the histology of the liver was studied using Shikata's orcein staining method. Of the 6339 autopsies performed, 488 cases of atrophic liver cirrhosis (7.7%) and 303 cases of primary hepatocellular carcinoma (4.8%) were identified. These incidences of liver diseases were statistically significantly higher compared with those of national averages of Japan (5.2% and 3.5% respectively). A histological analysis of 953 cases indicated that 242 out of 488 cases of atrophic liver cirrhosis were associated with hepatocellular carcinoma (49.6%) and that 242 out of 303 cases of hepatocellular carcinoma were combined with atrophic liver cirrhosis (78.9%). No HBs-Ag was detected in the tissues of cases of acute liver atrophy or liver cirrhosis with the exception of atrophic liver cirrhosis. HBs-Ag was present in 6 out of 22 cases of subacute hepatitis (27.2%) and in 6 out of 37 chronic hepatitis (16.2%). The highest rate of detectable HBs-Ag was observed in the liver tissues of the subgroup of atrophic liver cirrhosis with hepatocellular carcinoma (60.6%). Among 196 cases of hepatocellular carcinoma examined, HBs-Ag was detected in 14 of those cases which did not exhibit atrophic liver cirrhosis. These results suggest that nepatocellular carcinoma can arise without setting of hepatitis B chronic liver cirrhosis and support the hypothesis that HBs-Ag may be directly oncogenic. Liver cell dysplasia was found in 69 out of 154 cases of atrophic liver cirrhosis with hepatocellular carcinoma (44.8%) and in 22 out of 122 cases of atrophic liver cirrhosis without hapatocellular carcinoma (18.0%). Furthermore, there was a strong correlation between the presence of HBs-Ag in the liver tissue of Nagayo's type B atrophic liver cirrhosis and the existence of cellular dysplasia. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 26, 号 3, p. 123-136, 発行日 1984-09-29 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00123-P00136 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 26(3). p123-136, 1984 |