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Risk Factors for Acquisition of Fluoroquinolone or Aminoglycoside Resistance in Addition to Carbapenem Resistance in Pseudomonas aeruginosa
http://hdl.handle.net/10069/37727
http://hdl.handle.net/10069/37727a39056a1-5a19-4a72-928e-a1dc6e9bc9a4
名前 / ファイル | ライセンス | アクション |
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OMJ11_92.pdf (473.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-08-18 | |||||
タイトル | ||||||
タイトル | Risk Factors for Acquisition of Fluoroquinolone or Aminoglycoside Resistance in Addition to Carbapenem Resistance in Pseudomonas aeruginosa | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Metallo-β-lactamase | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug resistance | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Infection control | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Antibiotic therapy | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kosai, Kosuke
× Kosai, Kosuke× Kaku, Norihito× Uno, Naoki× Saijo, Tomomi× Morinaga, Yoshitomo× Imamura, Yoshifumi× Hasegawa, Hiroo× Miyazaki, Taiga× Izumikawa, Koichi× Mukae, Hiroshi× Yanagihara, Katsunori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Carbapenems, fluoroquinolones (FQs), and aminoglycosides (AGs) are key drugs for treating Pseudomonas aeruginosa infections, and accumulation of drug resistances make antibiotic therapy difficult. Methods: We evaluated 169 patients with imipenem (IPM)-resistant P. aeruginosa and compared patient background and microbiological characteristics between groups with or without FQ resistance. Similar analyses were performed for AG. Results: Of the 169 IPM-resistant strains, 39.1% showed resistance to FQs and 7.1% to AGs. The frequency of exposure to FQs within 90 days previously was higher in the group with FQ resistance (45.5%) than in the group without FQ resistance (13.6%). Similarly, 33.3% of patients in the group with AG resistance had been previously administered AGs, higher than the 7.6% of patients without AG resistance. Frequencies of metallo-β-lactamase (MBL) production were higher in the group with FQ or AG resistance (16.7% or 33.3%) than in the group without FQ or AG resistance (2.9% or 6.4%). Multivariate analyses showed exposures to FQs or AGs were related to the respective resistances. MBL production was a common factor for resistance to FQs or AGs, in addition to IPM-resistant P. aeruginosa. Conclusion: As well as promoting appropriate use of antibiotics, MBL production should be detected as a target of intervention for infection control. |
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書誌情報 |
The Open Microbiology Journal 巻 11, p. 92-97, 発行日 2017-05-31 |
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出版者 | ||||||
出版者 | Bentham Open | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18742858 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.2174/1874285801711010092 | |||||
権利 | ||||||
権利情報 | c 2017 Kosai et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
関係URI | ||||||
関連名称 | http://hdl.handle.net/10069/38693 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | The Open Microbiology Journal, 11, pp.92-97; 2017 |