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Soymilk Improves Muscle Weakness in Young Ovariectomized Female Mice
http://hdl.handle.net/10069/37737
http://hdl.handle.net/10069/377377b008696-ee63-47e2-9bf2-2a071b374817
名前 / ファイル | ライセンス | アクション |
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Nutrients9_834.pdf (1.2 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-08-24 | |||||
タイトル | ||||||
タイトル | Soymilk Improves Muscle Weakness in Young Ovariectomized Female Mice | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | soymilk | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | estrogen | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | muscle weakness | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | satellite cells | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kitajima, Yuriko
× Kitajima, Yuriko× Ogawa, Shizuka× Egusa, Shintaro× Ono, Yusuke |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Estrogens play a key role in an extensive range of physiological functions in various types of tissues throughout the body in females. We previously showed that estrogen insufficiency caused muscle weakness that could be rescued by estrogen administration in a young female ovariectomized (OVX) mouse model. However, long-term estrogen replacement therapy increases risks of breast cancer and cardiovascular diseases. Soymilk contains plant-based protein and isoflavones that exert estrogen-like activity. Here we examined the effects of prolonged soymilk intake on muscle and its resident stem cells, called satellite cells, in the estrogen-insufficient model. Six-week-old C57BL/6 OVX female mice were fed with a dried soymilk-containing diet. We found that prolonged soymilk intake upregulated grip strength in OVX mice. Correspondingly, cross-sectional area of tibialis anterior muscle was significantly increased in OVX mice fed with soymilk. Furthermore, soymilk diet mitigated dysfunction of satellite cells isolated from OVX mice. Thus, these results indicated that prolonged soymilk intake is beneficial for improving muscle weakness in an estrogen-insufficient state in females. | |||||
書誌情報 |
Nutrients 巻 9, 号 8, p. 834, 発行日 2017-08-04 |
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出版者 | ||||||
出版者 | MDPI | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 20726643 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3390/nu9080834 | |||||
権利 | ||||||
権利情報 | c 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nutrients, 9(8), 834; 2017 |