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Early Inhibition of Glycosylation with Deoxynojirimycin Has No Effect on the Replication of Flavivirus West Nile
http://hdl.handle.net/10069/4665
http://hdl.handle.net/10069/4665ec85b64d-cd53-453b-b638-d9166aef1d20
名前 / ファイル | ライセンス | アクション |
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tm36_01_01_t.pdf (3.8 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | Early Inhibition of Glycosylation with Deoxynojirimycin Has No Effect on the Replication of Flavivirus West Nile | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Ng, Mah Lee
× Ng, Mah Lee× Aw, Lay Tin |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Deoxynojirimycin (dNM) is a specific and reversible inhibitor of the trimming actions of glucosidase I and II in the rough endoplasmic reticulum. The importance of the effects of dNM on the replication of West Nile (sarafend-glycosylated) and West Nile (Wengler-nonglycosylated) viruses were studied. It was found that dNM treatment increase the molecular weights of the E and prM proteins in both virus strains without affecting the yields of the virus. The intracellular transport of the E protein from the rough endoplasmic reticulum to Golgi apparatus was not affected despite the change in molecular weights. It would appear that the prevention of removal of glucose molecules by dNM did not affected the maturation of E protein or the virus. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 36, 号 1, p. 1-13, 発行日 1994-06-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00001-P00013 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 36(1). p1-13, 1994 |