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Immunopathological Characterization of liposome Adjuvant Coated with Mannan
http://hdl.handle.net/10069/4730
http://hdl.handle.net/10069/4730f09bbcb1-2ae7-4127-b2c1-05e2c4e81c65
名前 / ファイル | ライセンス | アクション |
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tm38_03_02_t.pdf (1.0 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | Immunopathological Characterization of liposome Adjuvant Coated with Mannan | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Skikata, Kohdo
× Skikata, Kohdo× Ohishi, Kazue× Kawai, Hiromi× Fukasawa, Masashi× Sakakibara, Ryuzo× Ishiguro, Masatsune× Itakura, Hideyo× Hatanaka, Masakazu× Sugimoto, Masanobu |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The adjuvant activity of liposomes coated with mannan-cholesterol was studied in mice. Ovalbumin (OVA) was reconstituted into liposomes as a model antigen. The adjuvant activity was assessed by the following two immunological responses: delayed-type hypersensitivity (DTH) footpad swelling responses and in vitro release of interferon-γ and interleukin-4 by regional lymph node cells. First, we studied dose effects on DTH responses of total lipid, mannan-cholesterol and OVA used for liposomes. The minimal doses per mouse required for the induction of optimal responses were as follows; 1μg of OVA, 10μg of mannan-cholesterol and 336μg of total lipid. Second, immunological and histopathological studies showed the following two points: 1) mannan-coated liposomes induced a tuberculintype DTH response while non-coated liposomes elicited a Jones-Mote reaction, and 2) mannan-coated liposomes induced obvious microabscesses but non-coated liposome did not. Third, the inoculation of mannan-coated liposomes rendered the regional lymph node cells to release a large amount of interferon-γ with little IL-4 against OVA while non-coated lipo-some released neither of the lymphokines. These results indicated that mannan-coated lipo-somes are a potent adjuvant to induce type 1 helper T cells but have a disadvantage to form microabscesses at the inoculation sites. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 38, 号 3/4, p. 91-99, 発行日 1997-03-24 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00091-P00099 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 38(3/4). p91-99, 1997 |