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Effects of Incremental Doses of Chloroquine Phosphate on the Formed Elements of Blood.
http://hdl.handle.net/10069/4750
http://hdl.handle.net/10069/4750cce79f5f-e523-48f6-974c-3b9c1dea5878
名前 / ファイル | ライセンス | アクション |
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tm40_01_01_t.pdf (558.7 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | Effects of Incremental Doses of Chloroquine Phosphate on the Formed Elements of Blood. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Othman, Timothy
× Othman, Timothy× Arowolo, R. O. A. |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Easy access to chloroquine (CQ) in many developing countries can result to intake of inappropriate doses. This study was therefore conducted to evaluate the acute effects of high doses of CQ on hematological parameters and plasma Na+and K+ concentrations. To do this, Swiss albino rats were administered incremental doses of CQ intraperitoneally at dose rates ranging between 0.5 to 8mg/kg b.wt. Two hours later, blood samples were taken and analysed. 8mg/kg b.wt of CQ induced significant decrease in red blood cells (RBC), hemoglobin (Hb) and significant increase in mean corpuscular volume (MCV). There was a significant increase in white blood cell count at all dose levels. Packed cell volume (PCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were not affected by all dose ranges. There was significant increase in plasma Na+ and K+ by dose rates of 4 and 8 mg/kg but not by lower doses. These data indicate that most CQ induced toxicities on the formed elements of blood occurs at doses greater than 4 times the standard therapeutic dose in rats. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 40, 号 1, p. 1-7, 発行日 1998-09-10 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00001-P00007 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 40(1). p1-7, 1998 |