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A Simple Method for Screening of Macrofilaricidal Compounds-The Inhibitory Effect of Substances on Phosphatase Activity of Adult Dirofilaria immitis
http://hdl.handle.net/10069/4755
http://hdl.handle.net/10069/47554f871d93-28ba-4955-aa78-6c05f095dc8e
名前 / ファイル | ライセンス | アクション |
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tm40_02_03_t.pdf (268.8 kB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||
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公開日 | 2006-04-26 | |||||
タイトル | ||||||
タイトル | A Simple Method for Screening of Macrofilaricidal Compounds-The Inhibitory Effect of Substances on Phosphatase Activity of Adult Dirofilaria immitis | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | departmental bulletin paper | |||||
著者 |
Maki, Jun
× Maki, Jun× Kuwata, Masahiro× Mitsui, Yoshinori× Fujimaki, Yasunori× Ito, Yoichi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | A simple and reproducible screening method of macrofilaricides is described. The method evaluated in the present paper is based on inhibitory activity of the drugs on acid-phosphatase of Dirofilaria immitis adult worms. The potent inhibitor of acid-phosphates, NaF, inhibited completely the enzymic activity at 1 mM. trimelarsan, suramin and flubendazole inhibited partially the enzymic activity. Their inhibitory activity is comparable to that of Na_2HAsO_4, a specific inhibitor of phosphatase. Diethylcarbamazine and levamisole did not inhibit the phosphatase of D. immitis. | |||||
書誌情報 |
熱帯医学 Tropical medicine 巻 40, 号 2, p. 95-97, 発行日 1998-10-30 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 03855643 | |||||
書誌レコードID | ||||||
収録物識別子タイプ | NCID | |||||
収録物識別子 | AN00199644 | |||||
出版者 | ||||||
出版者 | 長崎大学熱帯医学研究所 | |||||
出版者別言語 | ||||||
Institute of Tropical Medicine, Nagasaki University | ||||||
sortkey | ||||||
P00095-P00097 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 熱帯医学 Tropical medicine 40(2). p95-97, 1998 |