WEKO3
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Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension. Methods: To investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60?69 years who participated in general health checkup. Results: HDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. 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Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels
http://hdl.handle.net/10069/37783
http://hdl.handle.net/10069/37783e02ea8fd-f0d0-458a-be8d-c6a9234f7d89
名前 / ファイル | ライセンス | アクション |
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JPA36_26.pdf (411.1 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-09-26 | |||||
タイトル | ||||||
タイトル | Association between high-density lipoprotein-cholesterol and hypertension in relation to circulating CD34-positive cell levels | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | HDL-cholesterol | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Circulating CD34-positive cell | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Hypertension | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimizu, Yuji
× Shimizu, Yuji× Sato, Shimpei× Koyamatsu, Jun× Yamanashi, Hirotomo× Nagayoshi, Mako× Kadota, Koichiro× Kawashiri, Shin-Ya× Maeda, Takahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background: Although high-density lipoprotein-cholesterol (HDL) level is inversely correlated with cardiovascular events, HDL is also reported to be positively associated with hypertension, which is a known endothelial impairment factor. Since HDL mediates important protective actions on the vascular endothelium by increasing the number of circulating endothelial progenitor cells (CD34-positive cells), the level of circulating CD34-positive cells should influence the association between HDL and hypertension. Methods: To investigate the association between HDL and hypertension in relation to the level of circulating CD34-positive cells, we conducted a cross-sectional study of 477 elderly men aged 60?69 years who participated in general health checkup. Results: HDL was found to be significantly positively associated with hypertension in subjects with a high level of circulating CD34-positive cells, while no significant association was observed for subjects with low circulating CD34-positive cells. Known cardiovascular risk factors adjusted odds (ORs) and 95% confidence intervals (CIs) of hypertension for increments of one standard deviation (SD) in HDL (13.8 mg/dL) were 1.44 (1.06, 1.96) for subjects with a high level of circulating CD34-positive cells and 0.87 (0.63, 1.19) for subjects with low circulating CD34-positive cells. We also revealed a significant association between HDL level and CD34-positive cell level on hypertension, with fully adjusted p values for the effect of this interaction on hypertension at 0.022. Conclusions: Independent of known cardiovascular risk factors, HDL was found to be positively associated with hypertension in subjects with a high level of circulating CD34-positive cells but not for subjects with low circulating CD34-positive cells. | |||||
書誌情報 |
Journal of Physiological Anthropology 巻 36, p. 26, 発行日 2017-06-15 |
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出版者 | ||||||
出版者 | 日本生理人類学会 | |||||
出版者別言語 | ||||||
Japan Society of Physiological Anthropology | ||||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 18806805 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/s40101-017-0143-9 | |||||
権利 | ||||||
権利情報 | c The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Physiological Anthropology, 36, 26; 2017 |