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Effects of monthly intravenous ibandronate on bone mineral density and microstructure in patients with primary osteoporosis after teriparatide treatment: The MONUMENT study
http://hdl.handle.net/10069/00040477
http://hdl.handle.net/10069/00040477084c6dba-6d00-4a66-9371-3414a1d38499
名前 / ファイル | ライセンス | アクション |
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Bone144_115770.pdf (2.1 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-01-26 | |||||
タイトル | ||||||
タイトル | Effects of monthly intravenous ibandronate on bone mineral density and microstructure in patients with primary osteoporosis after teriparatide treatment: The MONUMENT study | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Bone microstructure | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | High-resolution peripheral quantitative CT (HR-pQCT) | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Ibandronate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Monthly intravenous ibandronate | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Sequential therapy | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Teriparatide | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Chiba, Ko
× Chiba, Ko× Yamada, Shuta× Yoda, Itaru× Era, Makoto× Yokota, Kazuaki× Okazaki, Narihiro× Ota, Shingo× Isobe, Yusaku× Miyazaki, Satsuki× Tashiro, Shigeki× Nakashima, Sawako× Morimoto, Shimpei× Sato, Shuntaro× Tsukazaki, Tomoo× Watanabe, Tsuyoshi× Enomoto, Hiroshi× Yabe, Yoshihiro× Yonekura, Akihiko× Tomita, Masato× Ito, Masako× Osaki, Makoto |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: To investigate the effects of sequential therapy with monthly intravenous ibandronate on bone mineral density (BMD) and microstructure in patients with primary osteoporosis who received teriparatide treatment. Methods: Sixty-six patients with primary osteoporosis who had undergone teriparatide treatment for more than 12 months (mean 18.6 months) received sequential therapy with 1 mg/month intravenous ibandronate for 12 months. The patients were evaluated using dual-energy X-ray absorptiometry (DXA), quantitative ultrasound, bone turnover markers, and high-resolution peripheral quantitative computed tomography (HR-pQCT) at baseline and 6 and 12 months after beginning administration. Results: At 12 months after beginning sequential therapy,the bone resorption marker, tartrate-resistant acid phosphatase-5b, decreased by 39.5%, with 82.3% of the patients exhibiting levels within the normal limit. DXA revealed that the BMD of the lumbar spine increased by 3.2%, with 79.0% of the patients exhibiting a response, and 40.3% experiencing an increase in BMD over 5%. HR-pQCT revealed that the cortical thickness of the distal tibia was increased by 2.6%. The cortical area increased by 2.5%, and the buckling ratio (an index of cortical instability) decreased by 2.5%. Most parameters of the trabecular bone showed no significant changes. These changes in the cortical bone were observed in both the distal radius and tibia and appeared beginning 6 months after treatment initiation. Conclusions: Sequential therapy with monthly intravenous ibandronate increased the BMD and improved the cortical bone microstructure of osteoporotic patients who had undergone teriparatide treatment. | |||||
書誌情報 |
Bone 巻 144, p. 115770, 発行日 2020-11-27 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 87563282 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.bone.2020.115770 | |||||
権利 | ||||||
権利情報 | ©2020 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Bone, 144, art.no.115770; 2020 |