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Effect of the anti-parasitic compounds pyrvinium pamoate and artemisinin in enzymatic and culture assays: Data on the search for new anti-echinococcal drugs
http://hdl.handle.net/10069/00040480
http://hdl.handle.net/10069/00040480f611ac26-e504-4e57-a4df-a3dcc60bbf95
名前 / ファイル | ライセンス | アクション |
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DB34_106629.pdf (361.0 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-01-26 | |||||
タイトル | ||||||
タイトル | Effect of the anti-parasitic compounds pyrvinium pamoate and artemisinin in enzymatic and culture assays: Data on the search for new anti-echinococcal drugs | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Artemisinin | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Atovaquone | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Drug target | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Echinococcosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Echinococcus multilocularis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Mitochondria | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Pyrvinium pamoate | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Enkai, Shigehiro
× Enkai, Shigehiro× Kouguchi, Hirokazu× Inaoka, Daniel Ken× Irie, Takao× Yagi, Kinpei× Kita, Kiyoshi |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The dataset presented herein is related to a previous research article titled “Mitochondrial Complex III in Larval Stage of Echinococcus multilocularis as a Potential Chemotherapeutic Target and in vivo Efficacy of Atovaquone Against Primary Hydatid Cysts” [1]. In this report, data were collected by screening drugs for echinococcosis. We investigated the inhibitory activities of artemisinin and pyrvinium pamoate against the mitochondrial respiratory enzymes in E. multilocularis protoscoleces. Artemisinin did not inhibit mitochondrial complexes I, II, and III. However, pyrvinium pamoate inhibited complex I at 11 μM,although complexes II and III were not inhibited. In the culture assay, E. multilocularis protoscoleces were treated with atovaquone (ATV), rotenone, praziquantel, artemisinin, and pyrvinium pamoate at a final concentration of 50 µM in different culture media. The viability of protoscoleces was compared under aerobic and anaerobic conditions via culture experiments. The survival days of E. multilocularis protoscoleces were evaluated in the drug-treated group compared with those in the non-treated group. The results of these culture assays revealed that praziquantel and artemisinin did not eliminate the protoscoleces under both aerobic and anaerobic conditions. However, a stronger elimination ability was observed with the co-administration of praziquantel or artemisinin with ATV than with ATV alone under aerobic conditions. Pyrvinium pamoate completely killed protoscoleces at 5 and 7 days under aerobic and anaerobic conditions, respectively. Pyrvinium pamoate behaved identically to rotenone, the complex I inhibitor, in the culture treatment assay.The data serve as a reference for the development of novel anti-echinococcal drugs. | |||||
書誌情報 |
Data in Brief 巻 34, p. 106629, 発行日 2020-12-09 |
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出版者 | ||||||
出版者 | Elsevier Inc. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 23523409 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.dib.2020.106629 | |||||
権利 | ||||||
権利情報 | © 2020 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/) | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Data in Brief, 34, art.no.106629; 2020 |