WEKO3
アイテム
{"_buckets": {"deposit": "2c846ce0-4fd8-4bd0-b3da-75b0eaa1591f"}, "_deposit": {"created_by": 6, "id": "26335", "owners": [6], "pid": {"revision_id": 0, "type": "depid", "value": "26335"}, "status": "published"}, "_oai": {"id": "oai:nagasaki-u.repo.nii.ac.jp:00026335", "sets": ["26"]}, "author_link": ["117270", "117267", "117264", "117269", "117268", "117281", "117272", "117277", "117276", "117265", "117273", "117266", "117278", "117275", "117279", "117274", "117280", "117271"], "item_2_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2021-01-22", "bibliographicIssueDateType": "Issued"}, "bibliographicPageStart": "543500", "bibliographicVolumeNumber": "11", "bibliographic_titles": [{"bibliographic_title": "Frontiers in Endocrinology"}]}]}, "item_2_description_4": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Objective: Risk for developing papillary thyroid carcinoma (PTC), the most common endocrine malignancy, is thought to be mediated by lifestyle, environmental exposures and genetic factors. Recent progress in the genome-wide association studies of thyroid cancer leads to the identification of several genetic variants conferring risk to this malignancy across different ethnicities. We set out to elucidate the impact of selected single nucleotide polymorphisms (SNPs) on PTC risk and to evaluate clinicopathological correlations of these genetic variants in the Kazakh population for the first time. Methods: Eight SNPs were genotyped in 485 patients with PTC and 1,008 healthy control Kazakh subjects. The association analysis and multivariable modeling of PTC risk by the genetic factors, supplemented with rigorous statistical validation, were performed. Result: Five of the eight SNPs: rs965513 (FOXE1/PTCSC2, P = 1.3E-16), rs1867277 (FOXE1 5’UTR, P = 7.5E-06), rs2439302 (NRG1 intron 1, P = 4.0E-05), rs944289 (PTCSC3/NKX2-1, P = 4.5E-06) and rs10136427 (BATF upstream, P = 9.8E-03) were significantly associated with PTC. rs966423 (DIRC3, P = 0.07) showed a suggestive association. rs7267944 (DHX35) was associated with PTC risk in males (P = 0.02), rs1867277 (FOXE1) conferred the higher risk in subjects older than 55 years (P = 7.0E-05), and rs6983267 (POU5F1B/CCAT2) was associated with pT3–T4 tumors (P = 0.01). The contribution of genetic component (unidirectional independent effects of rs965513, rs944289, rs2439302 and rs10136427 adjusted for age and sex) to PTC risk in the analyzed series was estimated to be 30–40%. Conclusion: Genetic factors analyzed in the present work display significant association signals with PTC either on the whole group analysis or in particular clinicopathological groups and account for about one-third of the risk for PTC in the Kazakh population.", "subitem_description_type": "Abstract"}]}, "item_2_description_63": {"attribute_name": "引用", "attribute_value_mlt": [{"subitem_description": "Frontiers in Endocrinology, 11, art.no.543500; 2021", "subitem_description_type": "Other"}]}, "item_2_publisher_33": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Frontiers Media S.A."}]}, "item_2_relation_12": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isIdenticalTo", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3389/fendo.2020.543500", "subitem_relation_type_select": "DOI"}}]}, "item_2_rights_13": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2021 Mussazhanova, Rogounovitch, Saenko, Krykpayeva, Espenbetova, Azizov, Kondo, Matsuda, Kalmatayeva, Issayeva, Yeleubayeva, Madiyeva,Mukanova, Sandybayev, Bolsynbekova, Kozykenova, Yamashita and Nakashima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. "}]}, "item_2_source_id_7": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1664-2392", "subitem_source_identifier_type": "ISSN"}]}, "item_2_version_type_16": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Mussazhanova, Zhanna"}], "nameIdentifiers": [{"nameIdentifier": "117264", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Rogounovitch, Tatiana I."}], "nameIdentifiers": [{"nameIdentifier": "117265", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saenko, Vladimir A."}], "nameIdentifiers": [{"nameIdentifier": "117266", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Krykpayeva, Ainur"}], "nameIdentifiers": [{"nameIdentifier": "117267", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Espenbetova, Maira"}], "nameIdentifiers": [{"nameIdentifier": "117268", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Azizov, Bauyrzhan"}], "nameIdentifiers": [{"nameIdentifier": "117269", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kondo, Hisayoshi"}], "nameIdentifiers": [{"nameIdentifier": "117270", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Matsuda, Katsuya"}], "nameIdentifiers": [{"nameIdentifier": "117271", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kalmatayeva, Zhanna"}], "nameIdentifiers": [{"nameIdentifier": "117272", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Issayeva, Raushan"}], "nameIdentifiers": [{"nameIdentifier": "117273", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yeleubayeva, Zhanar"}], "nameIdentifiers": [{"nameIdentifier": "117274", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Madiyeva, Madina"}], "nameIdentifiers": [{"nameIdentifier": "117275", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mukanova, Aray"}], "nameIdentifiers": [{"nameIdentifier": "117276", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sandybayev, Marat"}], "nameIdentifiers": [{"nameIdentifier": "117277", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Bolsynbekova, Saltanat"}], "nameIdentifiers": [{"nameIdentifier": "117278", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kozykenova, Zhanna"}], "nameIdentifiers": [{"nameIdentifier": "117279", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamashita, Shunichi"}], "nameIdentifiers": [{"nameIdentifier": "117280", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakashima, Masahiro"}], "nameIdentifiers": [{"nameIdentifier": "117281", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2021-03-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "FE11_543500.pdf", "filesize": [{"value": "505.3 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 505300.0, "url": {"label": "FE11_543500.pdf ", "url": "https://nagasaki-u.repo.nii.ac.jp/record/26335/files/FE11_543500.pdf"}, "version_id": "54bf208e-1986-45f6-a490-1db872c84976"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "case–control genetic association study", "subitem_subject_scheme": "Other"}, {"subitem_subject": "clinicopathological correlation", "subitem_subject_scheme": "Other"}, {"subitem_subject": "spapillary thyroid carcinoma", "subitem_subject_scheme": "Other"}, {"subitem_subject": "risk factors for thyroid cancer", "subitem_subject_scheme": "Other"}, {"subitem_subject": "single nucleotide polymorphism", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations"}]}, "item_type_id": "2", "owner": "6", "path": ["26"], "permalink_uri": "http://hdl.handle.net/10069/00040533", "pubdate": {"attribute_name": "公開日", "attribute_value": "2021-03-02"}, "publish_date": "2021-03-02", "publish_status": "0", "recid": "26335", "relation": {}, "relation_version_is_last": true, "title": ["The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations"], "weko_shared_id": -1}
The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations
http://hdl.handle.net/10069/00040533
http://hdl.handle.net/10069/000405339cf80466-277e-4259-816c-0fc3ac23b583
名前 / ファイル | ライセンス | アクション |
---|---|---|
FE11_543500.pdf (505.3 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2021-03-02 | |||||
タイトル | ||||||
タイトル | The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | case–control genetic association study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | clinicopathological correlation | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | spapillary thyroid carcinoma | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | risk factors for thyroid cancer | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | single nucleotide polymorphism | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Mussazhanova, Zhanna
× Mussazhanova, Zhanna× Rogounovitch, Tatiana I.× Saenko, Vladimir A.× Krykpayeva, Ainur× Espenbetova, Maira× Azizov, Bauyrzhan× Kondo, Hisayoshi× Matsuda, Katsuya× Kalmatayeva, Zhanna× Issayeva, Raushan× Yeleubayeva, Zhanar× Madiyeva, Madina× Mukanova, Aray× Sandybayev, Marat× Bolsynbekova, Saltanat× Kozykenova, Zhanna× Yamashita, Shunichi× Nakashima, Masahiro |
|||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Objective: Risk for developing papillary thyroid carcinoma (PTC), the most common endocrine malignancy, is thought to be mediated by lifestyle, environmental exposures and genetic factors. Recent progress in the genome-wide association studies of thyroid cancer leads to the identification of several genetic variants conferring risk to this malignancy across different ethnicities. We set out to elucidate the impact of selected single nucleotide polymorphisms (SNPs) on PTC risk and to evaluate clinicopathological correlations of these genetic variants in the Kazakh population for the first time. Methods: Eight SNPs were genotyped in 485 patients with PTC and 1,008 healthy control Kazakh subjects. The association analysis and multivariable modeling of PTC risk by the genetic factors, supplemented with rigorous statistical validation, were performed. Result: Five of the eight SNPs: rs965513 (FOXE1/PTCSC2, P = 1.3E-16), rs1867277 (FOXE1 5’UTR, P = 7.5E-06), rs2439302 (NRG1 intron 1, P = 4.0E-05), rs944289 (PTCSC3/NKX2-1, P = 4.5E-06) and rs10136427 (BATF upstream, P = 9.8E-03) were significantly associated with PTC. rs966423 (DIRC3, P = 0.07) showed a suggestive association. rs7267944 (DHX35) was associated with PTC risk in males (P = 0.02), rs1867277 (FOXE1) conferred the higher risk in subjects older than 55 years (P = 7.0E-05), and rs6983267 (POU5F1B/CCAT2) was associated with pT3–T4 tumors (P = 0.01). The contribution of genetic component (unidirectional independent effects of rs965513, rs944289, rs2439302 and rs10136427 adjusted for age and sex) to PTC risk in the analyzed series was estimated to be 30–40%. Conclusion: Genetic factors analyzed in the present work display significant association signals with PTC either on the whole group analysis or in particular clinicopathological groups and account for about one-third of the risk for PTC in the Kazakh population. | |||||
書誌情報 |
Frontiers in Endocrinology 巻 11, p. 543500, 発行日 2021-01-22 |
|||||
出版者 | ||||||
出版者 | Frontiers Media S.A. | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1664-2392 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3389/fendo.2020.543500 | |||||
権利 | ||||||
権利情報 | © 2021 Mussazhanova, Rogounovitch, Saenko, Krykpayeva, Espenbetova, Azizov, Kondo, Matsuda, Kalmatayeva, Issayeva, Yeleubayeva, Madiyeva,Mukanova, Sandybayev, Bolsynbekova, Kozykenova, Yamashita and Nakashima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Frontiers in Endocrinology, 11, art.no.543500; 2021 |