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Multicenter evaluation of molecular point-of-care testing and digital immunoassays for influenza virus A/B and respiratory syncytial virus in patients with influenza-like illness
http://hdl.handle.net/10069/00040547
http://hdl.handle.net/10069/000405473bbb11ff-da4c-4562-a808-9242b308c672
名前 / ファイル | ライセンス | アクション |
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JIC_Kaku2021.pdf (302.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2021-03-12 | |||||
タイトル | ||||||
タイトル | Multicenter evaluation of molecular point-of-care testing and digital immunoassays for influenza virus A/B and respiratory syncytial virus in patients with influenza-like illness | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Influenza | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Molecular diagnostic techniques | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Multicenter study | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Point-of-care | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Respiratory syncytial virus | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Kaku, Norihito
× Kaku, Norihito× Kodama, Hina× Akamatsu, Norihiko× Ota, Kenji× Kosai, Kosuke× Morinaga, Yoshitomo× Narita, Yusuke× Matsumoto, Yasushi× Matsushita, Tetsuro× Mizuta, Yohei× Izumikawa, Koichi× Mukae, Hiroshi× Yanagihara, Katsunori |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Introduction: Digital immunoassays (DIAs) and molecular point-of-care (POC) tests for influenza were recently developed. We aimed to evaluate and compare the positive rate with molecular POC tests and DIAs in detecting influenza virus A, B and respiratory syncytial virus (RSV). Methods: A prospective observational study was conducted in 2019–2020. Nasopharyngeal swab samples were collected from adult outpatients with influenza-like illness who visited four hospitals and clinics in Japan. DIAs were performed at each facility. The clinical diagnosis was determined based on the findings of DIAs, history taking, and physical assessment. Molecular POC test and reverse transcription polymerase chain reaction (RT-PCR) were performed later. Results: A total of 182 patients were evaluated. The positive rate for influenza virus with molecular POC test was significantly higher than that with DIAs (51.6% versus 40.7%, p = 0.046). In patients who tested positive for influenza virus with only molecular POC test, the presence of influenza virus was confirmed by RT-PCR. In a comparison between the patients who were positive for influenza virus with only molecular POC test and those with both molecular POC test and DIA, the percentage of patients who sought consultation within 18 h after the onset of symptoms was significantly higher in the molecular POC test only group than in the both methods group (70.0% versus 43.2%, p = 0.044). Conclusions: A molecular POC test could contribute to the accurate diagnosis of influenza in patients with influenza-like illness, especially those who visited a hospital immediately after the onset of symptoms. | |||||
書誌情報 |
Journal of Infection and Chemotherapy 発行日 2021-01-25 |
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出版者 | ||||||
出版者 | Elsevier Ltd | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1341321X | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1016/j.jiac.2021.01.010 | |||||
権利 | ||||||
権利情報 | © 2021 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ | |||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Journal of Infection and Chemotherapy, Article in Press. |