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Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese
http://hdl.handle.net/10069/37863
http://hdl.handle.net/10069/3786325f24502-c2bb-4e9b-b8cd-41a4b4f21b31
名前 / ファイル | ライセンス | アクション |
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Onco8_69362.pdf (977.6 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-10-30 | |||||
タイトル | ||||||
タイトル | Handgrip strength and subclinical carotid atherosclerosis in relation to platelet levels among hypertensive elderly Japanese | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | atherosclerosis | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | handgrip | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | hypertension | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | platelet | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | sarcopenia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Gerotarget | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
著者 |
Shimizu, Yuji
× Shimizu, Yuji× Sato, Shimpei× Koyamatsu, Jun× Yamanashi, Hirotomo× Nagayoshi, Mako× Kadota, Koichiro× Kawashiri, Shin-Ya× Inoue, Keita× Nagata, Yasuhiro× Maeda, Takahiro |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Age-related disruption of microvascular endothelium exacerbates hypertension and sarcopenia; and atherosclerosis is a well-known biological response to vascular endothelial injury. Therefore, prevalence of atherosclerosis among hypertensive elderly subjects may partly indicate the presence of an appropriate response to endothelial injury. We conducted a cross-sectional study of 795 elderly hypertensive Japanese subjects aged 60-89 years. Since platelet level is an indicator of vascular repair activity, subjects were stratified by platelet counts. No significant association between handgrip strength and subclinical carotid atherosclerosis (carotid intima-media thickness (CIMT) ?1.1mm) was observed for subjects with lower platelet counts, while a significant positive association was observed for subjects with higher platelets. Adjusted odds and 95% confidence intervals of subclinical carotid atherosclerosis for 1 standard deviation increments in handgrip strength were 0.86 (0.61, 1.22) for subjects with lower platelets and 1.82 (1.26, 2.64) for subjects with higher platelets. A positive association between handgrip strength and subclinical carotid atherosclerosis exists in hypertensive elderly subjects with higher, but not lower, platelet counts. These results lead us to speculate that subjects with a beneficial influence on prevention of sarcopenia (maintenance of handgrip strength) may possess the capacity of active endothelial repair that causes atherosclerosis. | |||||
書誌情報 |
Oncotarget 巻 8, 号 41, p. 69362-69369, 発行日 2017-09-01 |
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出版者 | ||||||
出版者 | Impact Journals LLC | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 19492553 | |||||
DOI | ||||||
関連タイプ | isIdenticalTo | |||||
識別子タイプ | DOI | |||||
関連識別子 | 10.18632/oncotarget.20618 | |||||
権利 | ||||||
権利情報 | c 2017 Impact Journals, LLC | |||||
権利 | ||||||
権利情報 | This article is licensed under a Creative Commons Attribution 3.0 License. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Oncotarget, 8(41), pp.69362-69369; 2017 |