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Clinical, virological and epidemiological characterization of dengue outbreak in Myanmar, 2015
http://hdl.handle.net/10069/37888
http://hdl.handle.net/10069/3788816ee3bfa-bc86-46ae-9240-6de935469a4a
名前 / ファイル | ライセンス | アクション |
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ISYK984_Kyaw.pdf (942.7 kB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2018-02-01 | |||||
タイトル | ||||||
言語 | en | |||||
タイトル | Clinical, virological and epidemiological characterization of dengue outbreak in Myanmar, 2015 | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Clinical | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | molecular epidemiology | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | Myanmar | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | viremia | |||||
キーワード | ||||||
主題Scheme | Other | |||||
主題 | 2015 dengue outbreak | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_db06 | |||||
資源タイプ | doctoral thesis | |||||
アクセス権 | ||||||
アクセス権 | open access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||
著者 |
Kyaw, Aung Kyaw
× Kyaw, Aung Kyaw |
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著者別名 | ||||||
姓名 | キョウ, アウン キョウ | |||||
抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Hospital-based surveillance was conducted at two widely separated regions in Myanmar during the 2015 dengue epidemic. Acute phase serum samples were collected from 332 clinically diagnosed dengue patients during the peak season of dengue cases. Viremia levels were measured by quantitative real-time PCR and plaque assays using FcγRIIA-expressing and non-FcγRIIA-expressing BHK cells to specifically determine the infectious virus particles. By serology and molecular techniques, 280/332 (84・3%) were confirmed as dengue patients. All four serotypes of dengue virus (DENV) were isolated from among 104 laboratory-confirmed patients including two cases infected with two DENV serotypes. High percentage of primary infection was noted among the severe dengue patients. Patients with primary infection or DENV IgM negative demonstrated significantly higher viral loads but there was no significant difference among the severity groups. Viremia levels among dengue patients were notably high for a long period which was assumed to support the spread of the virus by the mosquito vector during epidemic. Phylogenetic analyses of the envelope gene of the epidemic strains revealed close similarity with the strains previously isolated in Myanmar and neighboring countries. DENV-1 dominated the epidemic in 2015 and the serotype (except DENV-3) and genotype distributions were similar in both study sites. | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | 長崎大学学位論文 学位記番号:博(医歯薬)甲第984号 学位授与年月日:平成29年9月20日 | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Author: A. K. KYAW, M. M. NGWE TUN, M. L. MOI, T. NABESHIMA, K. T. SOE, S. M. THWE, A. A. MYINT, K. T. T. MAUNG, W. AUNG, D. HAYASAKA, C. C. BUERANO, K. Z. THANT and K. MORITA | |||||
内容記述 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Citation: Epidemiology & Infection, 145(9), pp.1886-1897; 2017 | |||||
書誌情報 |
Epidemiology and Infection 巻 145, 号 9, p. 1886-1897, 発行日 2017-09-20 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 09502688 | |||||
EISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 14694409 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1017/S0950268817000735 | |||||
権利 | ||||||
権利情報 | c Cambridge University Press 2017 | |||||
権利 | ||||||
権利情報 | This article has been published in a revised form in Epidemiology & Infection, http://doi.org/10.1017/S0950268817000735. This version is free to view and download for private research and study only. Not for re-distribution, re-sale or use in derivative works. | |||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
その他のタイトル | ||||||
その他のタイトル | 2015年にミャンマー国で発生したデング熱流行の臨床、ウイルス学、疫学解析 | |||||
出版者 | ||||||
出版者 | Cambridge University Press | |||||
関係URI | ||||||
識別子タイプ | HDL | |||||
関連識別子 | http://hdl.handle.net/10069/37795 | |||||
学位名 | ||||||
学位名 | 博士(医学) | |||||
学位授与機関 | ||||||
学位授与機関識別子Scheme | kakenhi | |||||
学位授与機関識別子 | 17301 | |||||
学位授与機関名 | Nagasaki University (長崎大学) | |||||
学位授与年月日 | ||||||
学位授与年月日 | 2017-09-20 | |||||
学位授与番号 | ||||||
学位授与番号 | 甲医歯薬第984号 | |||||
学位の種類 | ||||||
課程博士 | ||||||
引用 | ||||||
内容記述タイプ | Other | |||||
内容記述 | Nagasaki University (長崎大学), 博士(医学) (2017-09-20) |